Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters

被引：66

作者：

Kietzmann, Thomas ^{[1
]}

机构：

[1] Univ Oulu, Bioctr Oulu, Fac Biochem & Mol Med, SF-90220 Oulu, Finland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期

基金：

芬兰科学院;

关键词：

ROS; antioxidants; antioxidative enzymes; matrix; diet; fibrosis; homeostasis; hypoxia; HIF; liver; metabolic zonation; metabolism; morphogen signaling; optimization; pathology; regulatory network; sinusoid; Hepatocytes; NONALCOHOLIC FATTY LIVER; MANGANESE SUPEROXIDE-DISMUTASE; ADENOMATOUS POLYPOSIS-COLI; RENAL-CELL-CARCINOMA; HEPATITIS-C VIRUS; FACTOR-KAPPA-B; HEPATOCELLULAR-CARCINOMA; METABOLIC ZONATION; SIGNALING PATHWAY; GENE-EXPRESSION;

D O I：

10.3390/ijms20092347

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as -catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis.

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页数：23

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