The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis

被引：31

作者：

Davies, Erin L. ^{[1
]}

Lim, Jaclyn G. Y. ^{[1
]}

Joo, William J. ^{[1
]}

Tam, Cheuk Ho ^{[1
]}

Fuller, Margaret T. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Dev Biol, Sch Med, Beckman Ctr B300, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

来源：

DEVELOPMENTAL BIOLOGY | 2013年 / 373卷 / 02期

基金：

美国国家科学基金会;

关键词：

Drosophila; Spermatogenesis; Germline stem cell; Spermatogonia; Spermatocyte; Transcription; AXON GUIDANCE GENE; SELF-RENEWAL; SPERMATID DIFFERENTIATION; TERMINAL DIFFERENTIATION; DOMAIN PROTEINS; LINE; SPERMATOGENESIS; PROLIFERATION; COLLABORATE; COORDINATE;

D O I：

10.1016/j.ydbio.2012.11.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cell behavior is regulated by extrinsic signals from specialized microenvironments, or niches, and intrinsic factors required for execution of context-appropriate responses to niche signals. Here we show that function of the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenance in the Drosophila testis. In addition, lola is also required for proper execution of key developmental transitions during male germ cell differentiation, including the switch from transit amplifying progenitor to spermatocyte growth and differentiation, as well as meiotic cell cycle progression and spermiogenesis. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages. (C) 2012 Published by Elsevier Inc.

引用

页码：310 / 321

页数：12

共 41 条

[1] The axon guidance gene lola is required for programmed cell death in the Drosophila ovary [J].

Bass, B. Paige ;

Cullen, Kristen ;

McCall, Kimberly .

DEVELOPMENTAL BIOLOGY, 2007, 304 (02) :771-785

[2] Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis [J].

Boyle, Monica ;

Wong, Chihunt ;

Rocha, Michael ;

Jones, D. Leanne .

CELL STEM CELL, 2007, 1 (04) :470-478

[3] Plzf is required in adult male germ cells for stem cell self-renewal [J].

Buaas, FW ;

Kirsh, AL ;

Sharma, M ;

McLean, DJ ;

Morris, JL ;

Griswold, MD ;

de Rooij, DG ;

Braun, RE .

NATURE GENETICS, 2004, 36 (06) :647-652

[4] Molecular cloning and characterization of a transcription factor for the copia retrotransposon with homology to the BTB-containing lola neurogenic factor [J].

Cavarec, L ;

Jensen, S ;

Casella, JF ;

Cristescu, SA ;

Heidmann, T .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (01) :482-494

[5] Tissue-specific TAFs counteract polycomb to turn on terminal differentiation [J].

Chen, X ;

Hiller, M ;

Sancak, Y ;

Fuller, MT .

SCIENCE, 2005, 310 (5749) :869-872

[6] All in the family: the BTB/POZ, KRAB, and SCAN domains [J].

Collins, T ;

Stone, JR ;

Williams, AJ .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) :3609-3615

[7] Essential role of Plzf in maintenance of spermatogonial stem cells [J].

Costoya, JA ;

Hobbs, RM ;

Barna, M ;

Cattoretti, G ;

Manova, K ;

Sukhwani, M ;

Orwig, KE ;

Wolgemuth, DJ ;

Pandolfi, PP .

NATURE GENETICS, 2004, 36 (06) :653-659

[8]

Crowner D, 2002, DEVELOPMENT, V129, P1317

[9] Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing [J].

Ferres-Marco, D ;

Gutierrez-Garcia, I ;

Vallejo, DM ;

Bolivar, J ;

Gutierrez-Aviño, FJ ;

Dominguez, M .

NATURE, 2006, 439 (7075) :430-436

[10]

Fuller Margaret T., 1993, P71

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