T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

被引：1

作者：

de Miranda, Aline Silva ^{[1
,2
]}

Ferreira, Rodrigo Novaes ^{[1
,2
]}

Marciano Vieira, Erica Leandro ^{[2
]}

Sabino Abreu, Larissa Katharina ^{[1
]}

Brant, Fatima ^{[3
]}

Vieira, Luciene Bruno ^{[4
]}

Ribeiro, Fabiola Mara ^{[3
]}

Machado, Fabiana Simao ^{[3
]}

Rachid, Milene Alvarenga ^{[5
]}

Teixeira, Antonio Ludo ^{[6
]}

机构：

[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Morphol, Lab Neurobiol, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Sch Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pathol, Belo Horizonte, MG, Brazil

[6] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Neuropsychiat Program, Houston, TX 77030 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 330卷

关键词：

Malaria; Cerebral malaria; Chloroquine; MK801; T lymphocytes; Glutamate; D-ASPARTATE RECEPTOR; CEREBROSPINAL-FLUID; PROTECTS MICE; BLOOD-STAGE; CELL-DEATH; IFN-GAMMA; PATHOGENESIS; BRAIN; INTERLEUKIN-10; CHLOROQUINE;

D O I：

10.1016/j.jneuroim.2019.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.

引用

页码：5 / 11

页数：7

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