Functionalized SBA-15 for controlled release of poorly soluble drug, Erythromycin

SBA-15 was functionalized by 12-tungstophosphoric acid followed by loading of poorly water soluble drug, Erythromycin and Characterized by various physicochemical techniques such as TGA, FT-IR, Nitrogen adsorption-desorption, XRD and TEM. In-vitro controlled release studies of Erythromycin in Simulated Body Fluid were carried out under stirring as well as static conditions. In order to see the influence of inorganic moiety on release rate of drug, study was also carried out with Erythromycin loaded unfunctionalized SBA-15. A study on release mechanism and release kinetics using Higuchi model, Koresmeyer-Peppas model and Extended kinetic model shows that 12-tungstophosphoric acid has significant influence on the release rate of Erythromycin. (C) 2017 Elsevier Inc. All rights reserved.