Mast Cells and Angiogenesis in Human Plasma Cell Malignancies

被引：24
作者：
Ribatti, Domenico [1 ]
Tamma, Roberto [1 ]
Vacca, Angelo [2 ]
机构：
[1] Univ Bari, Dept Basic Med Sci Neurosci & Sensory Organs, Sch Med, I-70124 Bari, Italy
[2] Univ Bari, Sect Internal Med & Clin Oncol, Dept Biomed Sci & Human Oncol, Sch Med, I-70124 Bari, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 03期
关键词：
angiogenesis; anti-angiogenesis; mast cells; multiple myeloma; plasmocytoma; BONE-MARROW ANGIOGENESIS; FIBROBLAST-GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; HUMAN-BREAST-CANCER; MULTIPLE-MYELOMA; SOLITARY PLASMACYTOMA; MICROVASCULAR DENSITY; PROTUMORIGENIC ROLE; SECRETORY GRANULES; TRYPTASE ACTIVITY;
D O I：
10.3390/ijms20030481
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone marrow angiogenesis plays an important role in the pathogenesis and progression of hematological malignancies. It is well known that tumor microenvironment promotes tumor angiogenesis, proliferation, invasion, and metastasis, and also mediates mechanisms of therapeutic resistance. An increased number of mast cells has been demonstrated in angiogenesis associated with hematological tumors. In this review we focused on the role of mast cells in angiogenesis in human plasma cell malignancies. In this context, mast cells might act as a new target for the adjuvant treatment of these tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.
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页数：11
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