Human African Trypanosomiasis Progress and Stagnation

被引：37

作者：

Bottieau, Emmanuel ^{[1
]}

Clerinx, Jan ^{[1
]}

机构：

[1] Inst Trop Med, Dept Clin Sci, Natl Str 155, B-2000 Antwerp, Belgium

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 01期

关键词：

Human African trypanosomiasis; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Clinical presentation; Diagnosis; Treatment; BRUCEI-GAMBIENSE TRYPANOSOMIASIS; EFLORNITHINE COMBINATION THERAPY; RAPID DIAGNOSTIC-TEST; SLEEPING SICKNESS; ORAL FEXINIDAZOLE; CLINICAL-ASPECTS; MELARSOPROL; MULTICENTER; INFECTIONS;

D O I：

10.1016/j.idc.2018.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Control efforts have considerably reduced the prevalence of human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense in West/Central Africa and to Trypanosoma brucei rhodesiense in East Africa. Management of T brucei gambiense HAT has recently improved, with new antibody-based rapid diagnostic tests suited for mass screening and clinical care, and simpler treatments, including the nifurtimox-eflornithine combination therapy and the new oral drug fexinidazole to treat the second stage of the disease. In contrast, no major advance has been achieved for the treatment of T brucei rhodesiense HAT, a zoonosis that occasionally affects short-term travelers to endemic areas.

引用

页码：61 / +

页数：18

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