Human African Trypanosomiasis Progress and Stagnation

被引：37
作者：
Bottieau, Emmanuel [1 ]
Clerinx, Jan [1 ]
机构：
[1] Inst Trop Med, Dept Clin Sci, Natl Str 155, B-2000 Antwerp, Belgium
来源：
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 01期
关键词：
Human African trypanosomiasis; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Clinical presentation; Diagnosis; Treatment; BRUCEI-GAMBIENSE TRYPANOSOMIASIS; EFLORNITHINE COMBINATION THERAPY; RAPID DIAGNOSTIC-TEST; SLEEPING SICKNESS; ORAL FEXINIDAZOLE; CLINICAL-ASPECTS; MELARSOPROL; MULTICENTER; INFECTIONS;
D O I：
10.1016/j.idc.2018.10.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Control efforts have considerably reduced the prevalence of human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense in West/Central Africa and to Trypanosoma brucei rhodesiense in East Africa. Management of T brucei gambiense HAT has recently improved, with new antibody-based rapid diagnostic tests suited for mass screening and clinical care, and simpler treatments, including the nifurtimox-eflornithine combination therapy and the new oral drug fexinidazole to treat the second stage of the disease. In contrast, no major advance has been achieved for the treatment of T brucei rhodesiense HAT, a zoonosis that occasionally affects short-term travelers to endemic areas.
引用
收藏
页码：61 / +
页数：18
相关论文
共 79 条
  • [1] Aksoy S., 2017, PLOS NEGLECT TROP D, V11, P1, DOI DOI 10.1111/J.1755-6724.1942.MP223-4016.X
  • [2] Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Medecins Sans Frontieres Experience in the Democratic Republic of the Congo
    Alirol, Emilie
    Schrumpf, David
    Heradi, Josue Amici
    Riedel, Andrea
    de Patoul, Catherine
    Quere, Michel
    Chappuis, Francois
    [J]. CLINICAL INFECTIOUS DISEASES, 2013, 56 (02) : 195 - 203
  • [3] A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis
    Babokhov, Peter
    Sanyaolu, Adekunle O.
    Oyibo, Wellington A.
    Fagbenro-Beyioku, Adetayo F.
    Iriemenam, Nnaemeka C.
    [J]. PATHOGENS AND GLOBAL HEALTH, 2013, 107 (05) : 242 - 252
  • [4] Bisser S, 2016, PLOS NEGLECT TROP D, V10, P1
  • [5] Clinical aspects of 2541 patients with second stage human African trypanosomiasis
    Blum, J
    Schmid, C
    Burri, C
    [J]. ACTA TROPICA, 2006, 97 (01) : 55 - 64
  • [6] Clinical description of encephalopathic syndromes and risk factors for their occurrence and outcome during melarsoprol treatment of human African trypanosomiasis
    Blum, J
    Nkunku, S
    Burri, C
    [J]. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2001, 6 (05) : 390 - 400
  • [7] Sleeping hearts: the role of the heart in sleeping sickness (human African trypanosomiasis)
    Blum, Johannes A.
    Burri, Christian
    Hatz, Christoph
    Kazumba, Leon
    Mangoni, Patrick
    Zellweger, Michael J.
    [J]. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2007, 12 (12) : 1422 - 1432
  • [8] Sleeping glands? -: The role of endocrine disorders in sleeping sickness (Tb. gambiense human African trypanosomiasis)
    Blum, Johannes A.
    Schmid, Caecilia
    Hatz, Christoph
    Kazumba, Leon
    Mangoni, Patrick
    Rutishauser, Jonas
    la Torre, Anna
    Burri, Christian
    [J]. ACTA TROPICA, 2007, 104 (01) : 16 - 24
  • [9] BOA YF, 1988, B SOC PATHOL EXOT, V81, P427
  • [10] A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo
    Boelaert, Marleen
    Mukendi, Deby
    Bottieau, Emmanuel
    Lilo, Jean Roger Kalo
    Verdonck, Kristien
    Minikulu, Luigi
    Barbe, Barbara
    Gillet, Philippe
    Yansouni, Cedric P.
    Chappuis, Francois
    Lutumba, Pascal
    [J]. EBIOMEDICINE, 2018, 27 : 11 - 17
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