Cholesterol and other membrane active sterols: from membrane evolution to "rafts"

被引：146
作者：
Barenholz, Y [1 ]
机构：
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biochem, Lab Membrane & Liposomal Res, IL-91120 Jerusalem, Israel
来源：
PROGRESS IN LIPID RESEARCH | 2002年 / 41卷 / 01期
关键词：
D O I：
10.1016/S0163-7827(01)00016-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The appearance of "membrane-active sterols" in biological membranes of eukaryocytes is one of the major steps in membrane evolution. This is exemplified best by membrane-active sterols of mammalia. The effect of membrane-active sterols on controlling membrane permeability by reducing average "fluidity" and free volume is well established. Recently it became clear that cholesterol also has a key role in the lateral organization of membranes and free volume distribution. The latter two parameters seem to be involved in controlling membrane protein activity and "raft" formation. Such an effect allows for the fine tuning of membrane lipid composition, organization/dynamics, and function. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：1 / 5
页数：5
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