The Role of the Environmental Risk Factors in the Pathogenesis and Clinical Outcome of Atopic Dermatitis

被引：74

作者：

Bonamonte, Domenico ^{[1
]}

Filoni, Angela ^{[1
,2
]}

Vestita, Michelangelo ^{[3
]}

Romita, Paolo ^{[1
]}

Foti, Caterina ^{[1
]}

Angelini, Gianni ^{[1
]}

机构：

[1] Univ Bari, Sect Dermatol, Dept Biomed Sci & Human Oncol, 11 Piazza Giulio Cesare, I-70124 Bari, Italy

[2] San Gallicano Dermatol Inst, Via Elio Chianesi 53, I-00144 Rome, Italy

[3] Univ Bari, Dept Emergency & Organ Transplantat, Sect Plast & Reconstruct Surg, 11 Piazza Giulio Cesare, I-70124 Bari, Italy

来源：

BIOMED RESEARCH INTERNATIONAL | 2019年 / 2019卷

关键词：

FARM MILK CONSUMPTION; ALLERGIC DISEASES; HYGIENE HYPOTHESIS; BIRTH COHORT; BREAST-MILK; FATTY-ACIDS; ASTHMA; ECZEMA; CHILDREN; EXPOSURE;

D O I：

10.1155/2019/2450605

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Atopic dermatitis (AD) prevalence is rising worldwide. Literature data suggest the incidence of AD in developing countries is gradually getting close to that of developed ones, in which AD affects 20% of the paediatric population. Such an increment, associated with significant variations in prevalence among the various countries, underlines the importance of environmental factors in the disease onset. Among these, great importance is given to hygiene, intestinal microbiota, exposure to bacterial endotoxins, outdoor living with contact to animals, atmospheric pollution, weather, and diet. Genetic (alteration of the skin barrier function) as well as immunologic factors concur with the environmental ones. Only the systematical study of all these elements can best elucidate AD epidemiology.

引用

页数：11

共 184 条

[1]

AHN K, 2002, THE JOURNAL OF ALLER, V134, P993, DOI DOI 10.1016/J.JACI.2014.09.023

[2] Is atopic dermatitis associated with obesity? A systematic review of observational studies [J].