Sex-dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: The role of hippocampal BDNF level

被引：20
作者：
Sakhaie, Nona [1 ]
Sadegzadeh, Farshid [1 ]
Mohammadnia, Alireza [2 ]
Dadkhah, Masoumeh [3 ]
Saadati, Hakimeh [4 ,5 ]
机构：
[1] Ardabil Univ Med Sci, Fac Med, Ardebil, Iran
[2] Ardabil Univ Med Sci, Fac Med, Dept Basic Sci, Ardebil, Iran
[3] Ardabil Univ Med Sci, Pharmaceut Res Ctr, Ardebil, Iran
[4] Ardabil Univ Med Sci, Fac Med, Dept Physiol, Ardebil, Iran
[5] Ardabil Univ Med Sci, Physiol Studies Res Ctr, Ardebil, Iran
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2020年 / 80卷 / 05期
关键词：
anxiety like behaviors; BDNF; enriched environment; gender differences; recognition memory; TRAINING INCREASES SIZE; NEUROTROPHIC FACTOR; VOLUNTARY EXERCISE; REGULAR EXERCISE; SYNAPTIC PLASTICITY; SLEEP-DEPRIVATION; TERM-MEMORY; BRAIN; FEMALE; NEUROGENESIS;
D O I：
10.1002/jdn.10038
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Exposure to enriched environment (EE) has been indicated to enhance cognitive functions, hippocampal neural plasticity, neurogenesis, long-term potentiation, and levels of the brain-derived neurotrophic factor (BDNF) in laboratory animals. Also, studies on the sex-dependent effects of exposure to EE during adolescence on adult cognitive functions are less. This is important because the beneficial effects of EE may be predominant in the adolescence stage. Therefore, the present study was designed to compare the effects of EE during adolescence (PND21-PND60) on novel objective recognition memory (NORM), anxiety-like behaviors, and hippocampal BDNF mRNA level in the adult male and female rats. Assessment of NORM and anxiety-like behaviors has been done by novel objective recognition task, open field (OF), and elevated plus maze (EPM), respectively. The expression of BDNF mRNA level was also evaluated by quantitative RT-PCR. Our findings demonstrated that housing in the EE during adolescence improves NORM in adult male rats. Also, exposure to EE during adolescence had a different effect on anxiety-like behaviors in both sexes. Additionally, our results indicated an augmented BDNF level in the hippocampus of male and female rats. In conclusion, adolescent exposure to EE has sex-dependent effects on cognitive functions and anxiety-like behaviors and increases BDNF mRNA expression in the hippocampus of both male and female rats; thus, BDNF is an important factor that can mediate the beneficial effects of EE and running exercise on cognitive functions and psychiatric traits.
引用
收藏
页码：396 / 408
页数：13
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