Adipose tissue in control of metabolism

被引:484
作者
Luo, Liping [1 ]
Liu, Meilian [1 ,2 ]
机构
[1] Cent South Univ, Key Lab Diabet Immunol, Xiangya Hosp 2,Metab Syndrome Res Ctr, Dept Metab & Endocrinol,Natl Clin Res Ctr Metab D, Changsha, Hunan, Peoples R China
[2] Univ New Mexico, Hlth Sci Ctr, Dept Biochem & Mol Biol, Albuquerque, NM 87131 USA
关键词
adipocytes; adipose tissue; adipogenesis; adipokines; thermogenesis; ACTIVATED-RECEPTOR-GAMMA; CENTRAL-NERVOUS-SYSTEM; INCREASES ENERGY-EXPENDITURE; DIET-INDUCED THERMOGENESIS; INDUCED BROWN ADIPOCYTES; SERUM RESISTIN LEVELS; FATTY-ACID OXIDATION; PPAR-GAMMA; INSULIN-RESISTANCE; C/EBP-ALPHA;
D O I
10.1530/JOE-16-0211
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity. Therefore, adipose tissue dysfunction plays a prominent role in the development of obesity and its related disorders such as insulin resistance, cardiovascular disease, diabetes, depression and cancer. In this review, we will summarize the recent findings of adipose tissue in the control of metabolism, focusing on its endocrine and thermogenic function.
引用
收藏
页码:R77 / R99
页数:23
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