Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

被引：262

作者：

Sette, Alessandro ^{[1
,2
]}

Crotty, Shane ^{[1
,2
]}

机构：

[1] La Jolla Inst Immunol, Ctr Infect Dis & Vaccine Res, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 08期

关键词：

D O I：

10.1038/s41577-020-0389-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating 'common cold' coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses. Recent studies have shown T cell reactivity to SARS-CoV-2 in 20-50% of unexposed individuals; it is speculated that this is due to T cell memory to common cold coronaviruses. Here, Crotty and Sette discuss the potential implications of these findings for disease severity, herd immunity and vaccine development.

引用

页码：457 / 458

页数：2

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