Amyotrophic Lateral Sclerosis: Modern Views on the Pathogenesis and Experimental Models

被引：5

作者：

Mukhamedyarov, M. A. ^{[1
]}

Petrov, A. M. ^{[1
,2
]}

Grigoryev, P. N. ^{[1
]}

Giniatullin, A. R. ^{[1
]}

Petukhova, E. O. ^{[1
]}

Zefirov, A. L. ^{[1
]}

机构：

[1] Kazan State Med Univ, Kazan, Russia

[2] RAS, Kazan Inst Biochem & Biophys, Kazan, Russia

来源：

ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2018年 / 68卷 / 05期

关键词：

neurodegenerative diseases; amyotrophic lateral sclerosis; neuromuscular synapse; superoxide dismutase 1; oxidative stress; neuroglia; transgenic animals; CU/ZN-SUPEROXIDE-DISMUTASE; MOTOR-NEURON DEGENERATION; NUCLEOTIDE EXCHANGE FACTOR; MYELINATING SCHWANN-CELLS; TRANSGENIC MOUSE MODEL; WILD-TYPE; MESSENGER-RNA; CHOLESTEROL-METABOLISM; DISEASE PROGRESSION; AXONAL-TRANSPORT;

D O I：

10.1134/S0044467718050106

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amyotrophic lateral sclerosis (ALS) is progressive incurable neurodegenerative disease which is characterized by selective loss of motoneurons of spinal cord and brain. Occupying the third place on prevalence among neurodegenerative diseases, ALS represents the significant medical and social problem of modern society. This review reflects the current understanding of genetic, cellular, molecular and synaptic mechanisms that determine ALS development, as well as the main experimental models used to study the mechanisms of pathogenesis and the development of approaches for treatment of ALS.

引用

页码：551 / 566

页数：16

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