Investigation of GPCR allosterism and dimerization in single living cells using fluorescent ligands

被引:0
作者
Hill, Stehen [1 ]
机构
[1] Univ Nottingham, Nottingham NG7 2RD, England
来源
SPRINGERPLUS | 2015年 / 4卷
关键词
Ligand binding; fluorescence; cooperativity; MEMBRANE MICRODOMAINS; RECEPTORS; KINETICS;
D O I
10.1186/2193-1801-4-S1-L8
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
L8
引用
收藏
页码:1 / 32
页数:1
相关论文
共 5 条
  • [1] Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells
    Cordeaux, Y.
    Briddon, S. J.
    Alexander, S. P. H.
    Kellam, B.
    Hill, S. J.
    [J]. FASEB JOURNAL, 2008, 22 (03) : 850 - 860
  • [2] Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism
    Corriden, Ross
    Kilpatrick, Laura E.
    Kellam, Barrie
    Briddon, Stephen J.
    Hill, Stephen J.
    [J]. FASEB JOURNAL, 2014, 28 (10) : 4211 - 4222
  • [3] Gherbi K, 2015, FASEB J
  • [4] Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics
    May, Lauren T.
    Bridge, Lloyd J.
    Stoddart, Leigh A.
    Briddon, Stephen J.
    Hill, Stephen J.
    [J]. FASEB JOURNAL, 2011, 25 (10) : 3465 - 3476
  • [5] The Effect of Allosteric Modulators on the Kinetics of Agonist-G Protein-Coupled Receptor Interactions in Single Living Cells
    May, Lauren T.
    Self, Tim J.
    Briddon, Stephen J.
    Hill, Stephen J.
    [J]. MOLECULAR PHARMACOLOGY, 2010, 78 (03) : 511 - 523