Influence of extracellular H+ and Ca2+ on Ro 22-9194-induced block of sodium current in cardiac myocytes

被引：0

作者：

Hisatome, I ^{[1
]}

Tanaka, Y ^{[1
]}

Sasaki, N ^{[1
]}

Hiroe, K ^{[1
]}

Ahmmed, GU ^{[1
]}

Tsuboi, M ^{[1
]}

Manabe, I ^{[1
]}

Suga, T ^{[1
]}

Yamamoto, Y ^{[1
]}

Ohtahara, A ^{[1
]}

Kinugawa, T ^{[1
]}

Ogino, K ^{[1
]}

Igawa, O ^{[1
]}

Yoshida, A ^{[1
]}

Saito, M ^{[1
]}

Sato, R ^{[1
]}

Shigemasa, C ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,SCH MED,DEPT MOL PHARMACOL & BIOL CHEM,CHICAGO,IL 60611

来源：

GENERAL PHARMACOLOGY | 1997年 / 29卷 / 04期

关键词：

Ro; 22-9194; Na+ channel; H+; Ca2+;

D O I：

10.1016/S0306-3623(96)00559-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Ro 22-9194 reduced the Na current in ventricular myocytes in either a tonic block or phasic block manner. 2. Ro 22-9194 had a higher affinity to the inactivated state (K-di=10.3 mu M) than to the rested state (K-drest=180 mu M). 3. Extracellular acidification enhanced the tonic block but reduced the phasic block. 4. Elevation of extracellular Ca2+ inhibited the enhancing effects of extracellular acidification. 5. These findings suggest that Ro 22-9194 strongly inhibits Na+ channels of the ventricular myocytes of the diseased hearts, characterized by the depolarized cell membranes and by acid conditions. (C) 1997 Elsevier Science Inc.

引用

页码：557 / 560

页数：4

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