Wild type and YMDD variant of hepatitis B virus: No difference in viral kinetics on lamivudine/tenofovir therapy in HIV-HBV co-infected patients

被引:13
作者
de Vries-Sluijs, TEMS
van der Eijk, AA
Hansen, BE
Osterhaus, ADME
de Man, RA
van der Ende, ME
机构
[1] Univ Med Ctr Rotterdam, ERASMUS MC, Dept Internal Med Infect Dis, NL-3015 GD Rotterdam, Netherlands
[2] Univ Med Ctr Rotterdam, ERASMUS MC, Dept Virol, Rotterdam, Netherlands
[3] Univ Med Ctr Rotterdam, ERASMUS MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands
[4] Univ Med Ctr Rotterdam, ERASMUS MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands
关键词
viral dynamics; lamivudine; tenofovir; HIV; HBV; YMDD;
D O I
10.1016/j.jcv.2005.12.004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Prolonged lamivudine therapy has been identified as the major risk for the development of resistance in HBV, with rates of 90% after 4 years of treatment. Tenofovir disoproxil fumarate showed activity against both wild type and lamivudine resistant HBV in HIV-HBV coinfected patients. In order to compare the efficacy of lamivudine/tenofovir treatment we investigated detailed HBV kinetics in 13 HIV-HBV co-infected patients with either wild type HBV or lamivudine resistant HBV. The viral strains in both patient groups showed a biphasic viral decline pattern. Only in the first phase of viral decay, which reflects the clearance rate of the free virus from plasma, there was a statistically significant response in favor of the wild type group. After the first phase we observed a similar viral decline till 24 weeks of both groups. This is reassuring for many pretreated co-infected patients harbouring Mutant viruses. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:60 / 63
页数:4
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