Synthesis of ciprofloxacin-based compounds: A review

被引：37

作者：

Akhtar, Rabia ^{[1
]}

Yousaf, Muhammad ^{[1
]}

Naqvi, Syed Ali Raza ^{[1
]}

Irfan, Muhammad ^{[2
]}

Zahoor, Ameer Fawad ^{[1
]}

Hussain, Abdullah Ijaz ^{[1
]}

Chatha, Shahzad Ali Shahid ^{[1
]}

机构：

[1] Govt Coll Univ, Inst Chem, Faisalabad 38000, Pakistan

[2] Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmaceut, Faisalabad, Pakistan

来源：

SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 23期

关键词：

Antibacterial; antibiotic; ciprofloxacin; fluoroquinolones; tuberculosis; VITRO ANTIBACTERIAL ACTIVITY; PIPERAZINYL QUINOLONE DERIVATIVES; FLUOROQUINOLONE DERIVATIVES; ANTIMYCOBACTERIAL EVALUATION; 1,2,4-TRIAZOLE-CIPROFLOXACIN HYBRIDS; BIOLOGICAL EVALUATION; POTENTIAL ANTITUMOR; ACID-DERIVATIVES; COUMARIN MOIETY; ANTI-HIV;

D O I：

10.1080/00397911.2016.1234622

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ciprofloxacin is a broad-spectrum antibiotic that plays an important role in inhibiting the growth of both Gram-positive and Gram-negative bacteria. Medicinal chemists are extensively involved in the synthesis of novel ciprofloxacin derivatives, in search of new ciprofloxacin-based drugs with enhanced activity. This review article summarizes the major synthetic approaches involved in the synthesis of ciprofloxacin-based molecules.

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页码：1849 / 1879

页数：31

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