Stemness in Hydra - a current perspective

被引：73

作者：

Hobmayer, Bert ^{[1
,2
]}

Jenewein, Marcell ^{[1
,2
]}

Eder, Dominik ^{[1
,2
]}

Eder, Marie-Kristin ^{[1
,2
]}

Glasauer, Stella ^{[1
,2
]}

Gufler, Sabine ^{[1
,2
]}

Hartl, Markus ^{[2
,3
]}

Salvenmoser, Willi ^{[1
,2
]}

机构：

[1] Univ Innsbruck, Inst Zool, Dept Evolutionary Dev Biol, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Ctr Mol Biosci, A-6020 Innsbruck, Austria

[3] Univ Innsbruck, Inst Biochem, A-6020 Innsbruck, Austria

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2012年 / 56卷 / 6-8期

基金：

奥地利科学基金会;

关键词：

Cnidaria; stem cell; self-renewal; Wnt; Myc; CELL-CYCLE KINETICS; SELF-RENEWAL PROBABILITY; DEVELOPMENTAL MECHANISMS; GENETIC-ANALYSIS; EPITHELIAL-CELLS; NERVE-CELL; DIFFERENTIATION PATHWAY; INTERSTITIAL-CELLS; PATTERN-FORMATION; WNT/BETA-CATENIN;

D O I：

10.1387/ijdb.113426bh

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hydra is a classic and simple model for pattern formation and regeneration research. More recently, it has also been promoted as a model to study ancestral stem cell biology. Three independent cell lineages form the body of the polyp and exhibit characteristics of stem cell systems. In order to define differences in sternness between the ectodermal and endodermal epitheliomuscular cell lineages and the interstitial cell lineage, we compare cellular properties and decision making. We argue that these three lineages are expected to show substantial variation in their sternness-related gene regulatory networks. Finally, we discuss Wnt signalling pathways and Myc oncoproteins, which are beginning to offer a perspective on how proliferation and differentiation might be regulated.

引用

页码：509 / 517

页数：9

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