The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

被引：687

作者：

Carmena, Mar ^{[1
]}

Wheelock, Michael ^{[2
]}

Funabiki, Hironori ^{[2
]}

Earnshaw, William C. ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

[2] Rockefeller Univ, New York, NY 10065 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 12期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

AURORA-B KINASE; CENTROMERE PROTEIN INCENP; KINETOCHORE-MICROTUBULE ATTACHMENT; MEDIATED ABSCISSION CHECKPOINT; HISTONE H3 PHOSPHORYLATION; SISTER-CHROMATID COHESION; CLEAVAGE FURROW FORMATION; KINESIN-LIKE PROTEIN; SPINDLE CHECKPOINT; INNER CENTROMERE;

D O I：

10.1038/nrm3474

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Successful cell division requires the precise and timely coordination of chromosomal, cytoskeletal and membrane trafficking events. These processes are regulated by the competing actions of protein kinases and phosphatases. Aurora B is one of the most intensively studied kinases. In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC). This complex targets to different locations at differing times during mitosis, where it regulates key mitotic events: correction of chromosome-microtubule attachment errors; activation of the spindle assembly checkpoint; and construction and regulation of the contractile apparatus that drives cytokinesis. Our growing understanding of the CPC has seen it develop from a mere passenger riding on the chromosomes to one of the main controllers of mitosis.

引用

页码：789 / 803

页数：15

共 251 条

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