Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities

被引：100

作者：

Xiao, WL

Yang, LM

Gong, NB

Wu, L

Wang, RR

Pu, JX

Li, XL

Huang, SX

Zheng, YT

Li, RT

Lu, Y

Zheng, QT

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[4] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 05期

关键词：

D O I：

10.1021/ol060062f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rubriflordilactones A (1) and B (2), two novel highly unsaturated rearranged bisnortriterpenoids possessing a biosynthetically modified aromatic D-ring, were isolated from the leaves and stems of Schisandra rubriflora. Their structures were established on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Compound 1 showed weak anti-HIV-1 activity, and compound 2 exhibited an EC50 value of 9.75 mu g/mL (SI = 12.39) against HIV-1 replication with low cytotoxicity.

引用

页码：991 / 994

页数：4

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