Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial

被引：33

作者：

Barakat, Sana Hosny ^{[1
]}

Meheissen, Marwa Ahmed ^{[2
]}

Omar, Omneya Magdy ^{[1
]}

Elbana, Doaa Ali ^{[1
]}

机构：

[1] Alexandria Univ, Fac Med, Dept Pediat, Alexandria 21131, Egypt

[2] Alexandria Univ, Fac Med, Dept Med Microbiol & Immunol, Alexandria 21131, Egypt

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2020年 / 66卷 / 01期

关键词：

bovine; colostrum; diarrhea; ESCHERICHIA-COLI; GLOBAL BURDEN; GASTROENTERITIS; IMMUNOGLOBULIN; INFANTS;

D O I：

10.1093/tropej/fmz029

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives: To evaluate the effect of bovine colostrum (BC) on the treatment of children with acute diarrhea attending the outpatient clinic. Methods: This double-blind randomized controlled trial was conducted on 160 children with diarrhea; 80 cases were randomly treated with BC group and 80 cases randomly received placebo (placebo group). All cases were investigated for bacterial causes of diarrhea (Salmonella spp, Shigella spp, diarrheagenic E. coli (DEC), Campylobacter spp., and Vibrio cholerae) as well as for Rotavirus antigen in stool. Results: After 48h, the BC group had a significantly lower frequency of vomiting, diarrhea and Vesikari scoring compared with the placebo group (p=0.000, p=0.000, p=0.000, respectively), whether it was due to Rotavirus or E. coli infection. Conclusions: BC is effective in the treatment of acute diarrhea and can be considered as adjuvant therapy in both viral and bacterial diarrhea to prevent diarrhea-related complications

引用

页码：46 / 55

页数：10

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