Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves

被引：16

作者：

Du, YH ^{[1
]}

Huang, SH ^{[1
]}

Tan, Z ^{[1
]}

Lin, YZ ^{[1
]}

Qiu, GY ^{[1
]}

机构：

[1] Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 1999年 / 44卷 / 08期

关键词：

ion implantation; gamma-rays; saddle types" curve; DNA single-strand breaks; curve fitting;

D O I：

10.1007/BF02909709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Calf thymus DNA was exposed to low-energy heavy ions (N+) and Co-60-gamma-rays, and the dose-effect on DNA single-strand breaks (SSB) has been investigated. The results indicate that the dose-effect curve by N+ irradiation is different from that of conventional ionizing radiation. While the curve from gamma-irradiation follows exponential type, the effect curve produced by N+ ion is of "saddle type". The yield of DNASSB per dose unit per DNA unit remained at a certain level under different doses of gamma-rays. In contrast, the DNASSB at low dosage region of N+ showed an obvious peak before it decreased rapidly to a lower level.

引用

页码：711 / 715

页数：5

共 6 条

[1] Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves
DU Yanhua
Chinese Science Bulletin, 1999, (08) : 711 - 715
[2] EFFECT OF IRON ACQUISITION ON INDUCTION OF DNA SINGLE-STRAND BREAKS BY ERIONITE, A CARCINOGENIC MINERAL FIBER
EBORN, SK
AUST, AE
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 316 (01) : 507 - 514
[3] DETERMINATION OF DNA SINGLE-STRAND BREAKS IN LYMPHOCYTES OF SMOKERS AND NONSMOKERS EXPOSED TO ENVIRONMENTAL TOBACCO-SMOKE USING THE NICK TRANSLATION ASSAY
EINHAUS, M
HOLZ, O
MEISSNER, R
KRAUSE, T
WARNCKE, K
HELD, I
SCHERER, G
TRICKER, AR
ADLKOFER, F
RUDIGER, HW
CLINICAL INVESTIGATOR, 1994, 72 (11): : 930 - 936
[4] EFFECT OF DIMETHYLTHIOUREA ON CHROMIUM (VI)-INDUCED DNA SINGLE-STRAND BREAKS IN CHINESE-HAMSTER V-79 CELLS
UENO, S
SUGIYAMA, M
SUSA, N
FURUKAWA, Y
MUTATION RESEARCH LETTERS, 1995, 346 (04): : 247 - 253
[5] Analysis of DNA single-strand breaks in human venous blood: A technique which does not require isolation of white blood cells
Hengstler, JG
Fuchs, J
Tanner, B
OeschBartlomowicz, B
Holz, C
Oesch, F
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1997, 29 (01) : 58 - 62
[6] Effect of high-dose low-energy reactive-ion implantation on cold cathode properties
Djurabekova, FG
Umirzakov, BE
Umarov, FF
Miyagawa, Y
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2003, 206 : 194 - 197

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