Spread of Influenza Virus A (H5N1) Clade 2.3.2.1 to Bulgaria in Common Buzzards

被引：24
作者：
Marinova-Petkova, Atanaska [1 ,2 ]
Georgiev, Georgi [2 ]
Seiler, Patrick [3 ]
Darnell, Daniel [3 ]
Franks, John [3 ]
Krauss, Scott [3 ]
Webby, Richard J. [3 ]
Webster, Robert G. [3 ]
机构：
[1] Reg Diagnost Lab Avian Influenza & Newcastle Dis, Varna, Bulgaria
[2] Natl Diagnost & Res Vet Med Inst, Sofia, Bulgaria
[3] St Jude Childrens Res Hosp, Memphis, TN 38105 USA
来源：
EMERGING INFECTIOUS DISEASES | 2012年 / 18卷 / 10期
基金：
美国国家卫生研究院;
关键词：
PANDEMIC H1N1 2009; AVIAN INFLUENZA; A H5N1; BIRDS; AMPLIFICATION; WATERFOWL; OUTBREAKS; ORIGIN;
D O I：
10.3201/eid1810.120357
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
On March 15, 2010, a highly pathogenic avian influenza virus was isolated from the Carcass of a common buzzard (Buteo buteo) in Bulgaria. Phylogenetic analyses of the virus showed a close genetic relationship with influenza virus A (H5N1) clade 2.3.2.1 viruses isolated from wild birds in the Tyva Republic and Mongolia during 2009-2010. Designated A/common buzzard/Bulgaria/38WB/2010, this strain was highly pathogenic in chickens but had low pathogenicity in mice and ferrets and no molecular markers of increased pathogenicity in mammals. The establishment of clade 2.3.2.1 highly pathogenic avian influenza viruses of the H5N1 subtype in wild birds in Europe would increase the likelihood of health threats to humans and poultry in the region.
引用
收藏
页码：1596 / 1602
页数：7
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