Effects of c-KIT mutations on expression of the RUNX1/RUNX1T1 fusion transcript in t(8;21)-positive acute myeloid leukemia patients

被引：13

作者：

Park, Sang Hyuk

Chi, Hyun-Sook ^{[1
]}

Cho, Young-Uk

Jang, Seongsoo

Park, Chan-Jeoung

机构：

[1] Univ Ulsan, Coll Med, Dept Lab Med, Seoul 138736, South Korea

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 07期

关键词：

AML; c-KIT; Effect; Quantitation; RUNX1/RUNX1T1; t(8; 21); CORE-BINDING-FACTOR; STEM-CELL FACTOR; PROGNOSTIC IMPACT; AML; T(8/21); FLT3; RECEPTOR; DISEASE; RAS;

D O I：

10.1016/j.leukres.2013.02.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RUNX1/RUNX1T1 fusion transcript expression less frequently than patients without mutations from 6 to 12 months of follow-up. They have difficulties to obtain molecular complete remission and experience molecular relapse more frequently and rapidly than those without mutations. These results support poor prognostic impact of c-KIT mutations in t(8;21)-positive AML. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：784 / 789

页数：6

共 14 条

[1]

[Anonymous], 2010, NCCN PRACTICE GUIDEL

[2] Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML) [J].

Boissel, N. ;

Leroy, H. ;

Brethon, B. ;

Philippe, N. ;

de Botton, S. ;

Auvrignon, A. ;

Raffoux, E. ;

Leblanc, T. ;

Thomas, X. ;

Hermine, O. ;

Quesnel, B. ;

Baruchel, A. ;

Leverger, G. ;

Dombret, H. ;

Preudhomme, C. .

LEUKEMIA, 2006, 20 (06) :965-970

[3] Prognostic impact of c-KIT mutations in core binding factor leukemas:: an Italian retrospective study [J].

Cairoli, R ;

Beghini, A ;

Grillo, G ;

Nadali, G ;

Elice, F ;

Ripamonti, CB ;

Colapietro, P ;

Nichelatti, M ;

Pezzetti, L ;

Lunghi, M ;

Cuneo, A ;

Viola, A ;

Ferrara, F ;

Lazzarino, M ;

Rodeghiero, F ;

Pizzolo, G ;

Larizza, L ;

Morra, E .

BLOOD, 2006, 107 (09) :3463-3468

[4] Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia [J].

Goemans, BF ;

Zwaan, CM ;

Miller, M ;

Zimmermann, M ;

Harlow, A ;

Meshinchi, S ;

Loonen, AH ;

Hählen, K ;

Reinhardt, D ;

Creutzig, U ;

Kaspers, GJL ;

Heinrich, MC .

LEUKEMIA, 2005, 19 (09) :1536-1542

[5] AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2 [J].

Jiao, B. ;

Wu, C-F ;

Liang, Y. ;

Chen, H-M ;

Xiong, S-M ;

Chen, B. ;

Shi, J-Y ;

Wang, Y-Y ;

Wang, J-H ;

Chen, Y. ;

Li, J-M ;

Gu, L-J ;

Tang, J-Y ;

Shen, Z-X ;

Gu, B-W ;

Zhao, W-L ;

Chen, Z. ;

Chen, S-J .

LEUKEMIA, 2009, 23 (09) :1598-1604

[6] KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor [J].

Kohl, TM ;

Schnittger, S ;

Ellwart, JW ;

Hiddemann, W ;

Spiekermann, K .

BLOOD, 2005, 105 (08) :3319-3321

[7] Monitoring of minimal residual disease in patients with core binding factor acute myeloid leukemia and the impact of C-KIT, FLT3, and JAK2 mutations on clinical outcome [J].

Markova, Jana ;

Trnkova, Zuzana ;

Michkova, Petra ;

Maaloufova, Jacqueline ;

Stary, Jan ;

Cetkovsky, Petr ;

Schwarz, Jiri .

LEUKEMIA & LYMPHOMA, 2009, 50 (09) :1448-1460

[8] Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia [J].

Park, Sang Hyuk ;

Chi, Hyun-Sook ;

Min, Sook-Kyung ;

Park, Borae G. ;

Jang, Seongsoo ;

Park, Chan-Jeoung .

LEUKEMIA RESEARCH, 2011, 35 (10) :1376-1383

[9] Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21):: A Cancer and Leukemia Group B study [J].

Paschka, Peter ;

Marcucci, Guido ;

Ruppert, Amy S. ;

Mrozek, Krzysztof ;

Chen, Hankui ;

Kittles, Rick A. ;

Vukosavljevic, Tamara ;

Perrotti, Danilo ;

Vardiman, James W. ;

Carroll, Andrew J. ;

Kolitz, Jonathan E. ;

Larson, Richard A. ;

Bloomfield, Clara D. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (24) :3904-3911

[10] Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML [J].

Pollard, Jessica A. ;

Alonzo, Todd A. ;

Gerbing, Robert B. ;

Ho, Phoenix A. ;

Zeng, Rong ;

Ravindranath, Yaddanapudi ;

Dahl, Gary ;

Lacayo, Norman J. ;

Becton, David ;

Chang, Myron ;

Weinstein, Howard J. ;

Hirsch, Betsy ;

Raimondi, Susana C. ;

Heerema, Nyla A. ;

Woods, William G. ;

Lange, Beverly J. ;

Hurwitz, Craig ;

Arceci, Robert J. ;

Radich, Jerald P. ;

Bernstein, Irwin D. ;

Heinrich, Michael C. ;

Meshinchi, Soheil .

BLOOD, 2010, 115 (12) :2372-2379

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