The SOX gene family: function and regulation in testis determination and male fertility maintenance

被引：75
作者：
Jiang, Ting [1 ]
Hou, Cong-Cong [1 ]
She, Zhen-Yu [1 ]
Yang, Wan-Xi [1 ]
机构：
[1] Zhejiang Univ, Inst Cell & Dev Biol, Coll Life Sci, Sperm Lab, Hangzhou 310058, Zhejiang, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2013年 / 40卷 / 03期
基金：
中国国家自然科学基金;
关键词：
SOX; SRY; SOX8; SOX9; Testis determination; Male fertility maintenance; MAMMALIAN SEX DETERMINATION; MULLERIAN HORMONE GENE; SRY-RELATED GENE; DNA-BINDING; GONADAL DIFFERENTIATION; CAMPOMELIC DYSPLASIA; DETERMINING REGION; SERTOLI CELLS; MOUSE; EXPRESSION;
D O I：
10.1007/s11033-012-2279-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Sox (Sry-type HMG box) genes encode a group of proteins characterized by the existence of an SRY (sex-determining region on Y chromosome) box, a 79 amino acid motif that encodes an HMG (high mobility group) domain which can bind and bend DNA, which is the only part in SRY that is conserved between species. The Sox gene family functions in many aspects in embryogenesis, including testis development, CNS neurogenesis, oligodendrocyte development, chondrogenesis, neural crest cell development and other respects. The Sox gene family was originally identified through homology with Sry. The Sry gene is the mammalian testis-determining gene. It functions to open the testis determination pathway directly and close the ovary pathway indirectly. Sry and Sox9 are the most important two genes expressed during testis determination. Besides, researchers have found that Sox8 and Sox9 have functions in the male fertility maintenance after birth. In this review, information was evaluated from mouse or from human if not mentioned otherwise.
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页码：2187 / 2194
页数：8
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