Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling

被引：293

作者：

Sennett, Rachel ^{[1
,2
]}

Rendl, Michael ^{[1
,2
,3
]}

机构：

[1] Mt Sinai Sch Med, Black Family Stem Cell Inst, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Dev & Regenerat Biol, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Dermatol, New York, NY 10029 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 08期

关键词：

Mesenchymal-epithelial interactions; Hair follicle; Stem cells; Dermal papilla; Signaling; DERMAL PAPILLA CELLS; BETA-CATENIN ACTIVITY; GROWTH-FACTOR RECEPTOR; MELANOCYTE STEM-CELLS; LABEL-RETAINING CELLS; SONIC-HEDGEHOG; TRANSIENT ACTIVATION; SIGNALING PATHWAYS; MOUSE DEVELOPMENT; MULTIPLE ROLES;

D O I：

10.1016/j.semcdb.2012.08.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Embryonic hair follicle induction and formation are regulated by mesenchymal-epithelial interactions between specialized dermal cells and epidermal stem cells that switch to a hair fate. Similarly, during postnatal hair growth, communication between mesenchymal dermal papilla cells and surrounding epithelial matrix cells coordinates hair shaft production. Adult hair follicle regeneration in the hair cycle again is thought to be controlled by activating signals originating from the mesenchymal compartment and acting on hair follicle stem cells. Although many signaling pathways are implicated in hair follicle formation and growth, the precise nature, timing, and intersection of these inductive and regulatory signals remains elusive. The goal of this review is to summarize our current understanding and to discuss recent new insights into mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：917 / 927

页数：11

共 161 条

[1] The hair cycle [J].