Important Unresolved Questions in the Management of Hepatic Encephalopathy: An ISHEN Consensus

被引：99

作者：

Bajaj, Jasmohan S. ^{[1
]}

Lauridsen, Mette ^{[2
]}

Tapper, Elliot B. ^{[3
]}

Duarte-Rojo, Andres ^{[4
]}

Rahimi, Robert S. ^{[5
]}

Tandon, Puneeta ^{[6
]}

Shawcross, Debbie L. ^{[7
]}

Thabut, Dominique ^{[8
]}

Dhiman, Radha K. ^{[9
]}

Romero-Gomez, Manuel ^{[10
]}

Sharma, Barjesh C. ^{[11
]}

Montagnese, Sara ^{[12
]}

机构：

[1] Virginia Commonwealth Univ, McGuire VA Med Ctr, Richmond, VA 23284 USA

[2] Hosp South West Jutland, Esbjerg, Denmark

[3] Univ Michigan, Ann Arbor, MI 48109 USA

[4] Univ Pittsburgh, Pittsburgh, PA USA

[5] Baylor Univ, Med Ctr, Dallas, TX USA

[6] Univ Alberta, Edmonton, AB, Canada

[7] Kings Coll Hosp London, London, England

[8] Paris Sorbonne Univ, Hop Pitie Salpetriere, Paris, France

[9] Postgrad Inst Med Educ & Res, Chandigarh, India

[10] Univ Seville, Seville, Spain

[11] GB Pant Hosp, New Delhi, India

[12] Univ Padua, Dept Med, Padua, Italy

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2020年 / 115卷 / 07期

关键词：

RANDOMIZED CONTROLLED-TRIAL; INTRAHEPATIC PORTOSYSTEMIC SHUNT; CRITICAL FLICKER FREQUENCY; ARTERIAL AMMONIA LEVELS; ORNITHINE L-ASPARTATE; QUALITY-OF-LIFE; BLOOD-AMMONIA; DOUBLE-BLIND; NUTRITIONAL SUPPLEMENTATION; CIRRHOTIC-PATIENTS;

D O I：

10.14309/ajg.0000000000000603

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Management of hepatic encephalopathy (HE) remains challenging from a medical and psychosocial perspective. Members of the International Society for Hepatic Encephalopathy and Nitrogen Metabolism recognized 5 key unresolved questions in HE management focused on (i) driving, (ii) ammonia levels in clinical practice, (iii) testing strategies for covert or minimal HE, (iv) therapeutic options, and (v) nutrition and patient-reported outcomes. The consensus document addresses these topical issues with a succinct review of the literature and statements that critically evaluate the current science and practice, laying the groundwork for future investigations.

引用

页码：989 / 1002

页数：14

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