Kainic acid activates oxytocinergic neurons through non-NMDA glutamate receptors

被引：7

作者：

Minbay, Fatma Zehra ^{[1
]}

Eyigor, Ozhan ^{[1
]}

Cavusoglu, Ilkin ^{[1
]}

机构：

[1] Uludag Univ, Fac Med, Dept Histol & Embryol, TR-16059 Bursa, Turkey

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2006年 / 116卷 / 05期

关键词：

CNQX; immunohistochemistry; kainate; oxytocin; PVN; SON;

D O I：

10.1080/00207450600592123

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study assessed if kainic acid activates oxytocinergic neurons and this activation is blocked by 6- cyano- 7- nitroquinoxaline- 2,3- dione ( CNQX). Dual immunohistochemistry for oxytocin and c- Fos showed that oxytocin neurons in SON and PVN express c- Fos following kainic acid administration, a significant increase when compared to the control group. Administration of CNQX prior to kainic acid caused a significant reduction. The results suggested the participation of non- NMDA receptors in the regulation of oxytocin neurons because the administration of kainic acid activates these neurons and this activation is blocked by CNQX administration.

引用

页码：587 / 600

页数：14

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