Highly Stable Hexacoordinated Nonoxidovanadium(IV) Complexes of Sterically Constrained Ligands: Syntheses, Structure, and Study of Antiproliferative and Insulin Mimetic Activity

被引：63

作者：

Dash, Subhashree P. ^{[1
]}

Pasayat, Sagarika ^{[1
]}

Bhakat, Saswati ^{[1
]}

Roy, Satabdi ^{[1
]}

Dinda, Rupam ^{[1
]}

Tiekink, Edward R. T. ^{[2
]}

Mukhopadhyay, Subhadip ^{[3
]}

Bhutia, Sujit K. ^{[3
]}

Hardikar, Manasi R. ^{[4
]}

Joshi, Bimba N. ^{[4
]}

Patil, Yogesh P. ^{[5
]}

Nethaji, M. ^{[5
]}

机构：

[1] Natl Inst Technol, Dept Chem, Rourkela 769008, Odisha, India

[2] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[3] Natl Inst Technol, Dept Life Sci, Rourkela 769008, Odisha, India

[4] Agharkar Res Inst, Biometry & Nutr Grp, Pune 411004, Maharashtra, India

[5] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

INORGANIC CHEMISTRY | 2013年 / 52卷 / 24期

关键词：

TRIGONAL-PRISMATIC COORDINATION; OXO VANADIUM(IV) COMPLEXES; SCHIFF-BASE LIGANDS; X-RAY-STRUCTURE; IN-VITRO; CRYSTAL-STRUCTURE; OXOVANADIUM(IV) COMPLEX; ANTITUMOR-ACTIVITY; ISONICOTINOYL HYDRAZONE; DONOR LIGANDS;

D O I：

10.1021/ic401866x

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three highly stable, hexacoordinated nonoxidovanadium(IV), V-IV(L)(2), complexes (1-3) have been isolated and structurally characterized with tridentate aroylhydrazonates containing ONO donor atoms. All the complexes are stable in the open air in the solid state as well as in solution, a phenomenon rarely observed in nonoxidovanadium(IV) complexes. The complexes have good solubility in organic solvents, permitting electrochemical and various spectroscopic investigations. The existence of nonoxidovanadium(IV) complexes was confirmed by elemental analysis, ESI mass spectroscopy, cyclic voltammetry, EPR, and magnetic susceptibility measurements. X-ray crystallography showed the N3O3 donor set to define a trigonal prismatic geometry in each case. All the complexes show in vitro insulin mimetic activity against insulin responsive L6 myoblast cells, with complex 3 being the most potent, which is comparable to insulin at the complex concentration of 4 mu M, while the others have moderate insulin mimetic activity. In addition, the in vitro antiproliferative activity of complexes 1-3 against the He La cell line was assayed. The cytotoxicity of the complexes is affected by the various functional groups attached to the bezoylhydrazone derivative and 2 showed considerable antiproliferative activity compared to the most commonly used chemotherapeutic drugs.

引用

页码：14096 / 14107

页数：12

共 156 条

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