Pathophysiology of trauma-induced coagulopathy: disseminated intravascular coagulation with the fibrinolytic phenotype

被引：63
作者：
Hayakawa, Mineji [1 ]
机构：
[1] Hokkaido Univ Hosp, Emergency & Crit Care Ctr, Kita Ku, N14W5, Sapporo, Hokkaido 0608648, Japan
来源：
JOURNAL OF INTENSIVE CARE | 2017年 / 5卷
关键词：
Coagulopathy; Disseminated intravascular coagulation; Fibrinolysis; Massive bleeding; Transfusion; Fibrinogen; Trauma; SOLUBLE THROMBOMODULIN ANTIGEN; MULTIPLE ORGAN DYSFUNCTION; ACTIVATED PROTEIN-C; BLUNT CHEST TRAUMA; GROUP BOX 1; MASSIVE TRANSFUSION; BRAIN-INJURY; THROMBIN GENERATION; PROSPECTIVE COHORT; TISSUE FACTOR;
D O I：
10.1186/s40560-016-0200-1
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
In severe trauma patients, coagulopathy is frequently observed in the acute phase of trauma. Trauma-induced coagulopathy is coagulopathy caused by the trauma itself. The pathophysiology of trauma-induced coagulopathy consists of coagulation activation, hyperfibrino(geno)lysis, and consumption coagulopathy. These pathophysiological mechanisms are the characteristics to DIC with the fibrinolytic phenotype.
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页数：7
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