COX-2 promotes metastasis and predicts prognosis in gastric cancer via regulating mTOR

被引：10

作者：

Xiang, Liangliang ^{[1
,2
]}

Wang, Weimin ^{[1
,2
,3
]}

Zhou, Zhen ^{[1
,2
]}

Lv, Mengying ^{[1
,2
]}

Tao, Li ^{[1
,2
]}

Ni, Tengyang ^{[1
,2
]}

Deng, Jianliang ^{[3
]}

Masatara, Sunagawa ^{[4
]}

Liu, Yanqing ^{[1
,2
,3
]}

Zhou, Yan ^{[1
,2
,3
]}

机构：

[1] Yangzhou Univ, Inst Translat Med, Coll Med, Yangzhou 225001, Jiangsu, Peoples R China

[2] State Adm Tradit Chinese Med, Key Lab Syndrome Differentiat & Treatment Gastr C, Tradit Chinese Med Adm, Yangzhou 225001, Jiangsu, Peoples R China

[3] Yangzhou Univ, Dept Oncol, Yixing Hosp, Coll Med, Yixing 214200, Jiangsu, Peoples R China

[4] Showa Univ, Sch Med, Dept Physiol, Tokyo 142, Japan

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 06期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

COX-2; gastric cancer; metastasis; mTOR; prognosis; METABOLISM; TARGET; INFLAMMATION; CULLIN1; MARKER;

D O I：

10.2217/bmm-2019-0357

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Gastric cancer (GC) is one of the most common malignant tumors in the world. It is important to find accurate and reliable biomarkers in order to decrease whole morbidity and mortality. Results: We examined the expression of COX-2 and mTOR on GC tissue microarrays by immunohistochemistry. Multi-variate COX regression analysis showed that the expression of COX-2 or mTOR was an independent factor in the prognosis of GC patients. In addition, COX-2 and mTOR had the potentially synergistic effect on predicting the prognosis of GC. Conclusion: The combined expression of COX-2 and mTOR could serve as efficient prognostic indicators and COX-2 could suppress GC metastasis via regulating mTOR.

引用

页码：421 / 432

页数：12

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