TDP-43 toxicity and the usefulness of junk

被引：3

作者：

Sun, Shuying ^{[1
]}

Cleveland, Don W.

机构：

[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 12期

基金：

英国惠康基金;

关键词：

FRONTOTEMPORAL LOBAR DEGENERATION; RNA TARGETS;

D O I：

10.1038/ng.2473

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

引用

页码：1289 / 1291

页数：3

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