TDP-43 toxicity and the usefulness of junk

被引：3
|
作者：
Sun, Shuying [1 ]
Cleveland, Don W.
机构：
[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
来源：
NATURE GENETICS | 2012年 / 44卷 / 12期
基金：
英国惠康基金;
关键词：
FRONTOTEMPORAL LOBAR DEGENERATION; RNA TARGETS;
D O I：
10.1038/ng.2473
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.
引用
收藏
页码：1289 / 1291
页数：3
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