pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland

被引：35

作者：

Seshaiah, P ^{[1
]}

Miller, B ^{[1
]}

Myat, MM ^{[1
]}

Andrew, DJ ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol & Anat, Baltimore, MD 21205 USA

来源：

DEVELOPMENTAL BIOLOGY | 2001年 / 239卷 / 02期

关键词：

Drosophila; KH-domain; morphogenesis; Nova-1; Nova-2; POMA; RNA-binding protein; salivary gland; secretion; splicing;

D O I：

10.1006/dbio.2001.0429

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

From a screen for genes expressed and required in the Drosophila salivary gland, we identified pasilla (ps), which encodes a set of proteins most similar to human Nova-1 and Nova-2. Nova-1 and Nova-2 are nuclear RNA-binding proteins normally expressed in the CNS where they directly regulate splicing. In patients suffering from paraneoplastic opsoclonus myoclonus ataxia (POMA), Nova-1 and Nova-2 proteins are present as auto-antigens. Consistent with a role in splicing, PS is localized to nuclear puncta. The salivary glands of ps mutants internalize normally and maintain epithelial polarity. However, the mutant salivary glands develop irregularities in overall morphology and have defects in apical secretion. The secretory defects in ps mutants provide a potential mechanism for the loss of motor function observed in POMA patients. (C) 2001 Academic Press.

引用

页码：309 / 322

页数：14