Azacitidine differentially affects CD4pos T-cell polarization in vitro and in vivo in high risk myelodysplastic syndromes

被引：37

作者：

Bontkes, Hetty J. ^{[1
]}

Ruben, Jurjen M. ^{[1
]}

Alhan, Canan ^{[1
]}

Westers, Theresia M. ^{[1
]}

Ossenkoppele, Gert J. ^{[1
]}

van de Loosdrecht, Arjan A. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Canc Ctr Amsterdam, Dept Hematol, NL-1081 HV Amsterdam, Netherlands

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 07期

关键词：

Azacitidine; Cytokines; Regulatory T cells; IL-17; CD4 T-helper cells; MDS; ACUTE MYELOID-LEUKEMIA; VERSUS-HOST-DISEASE; BONE-MARROW-CELLS; HUMAN TH17 CELLS; IFN-GAMMA GENE; DNA METHYLATION; PERIPHERAL-BLOOD; TUMOR-GROWTH; FOXP3; EXPRESSION;

D O I：

10.1016/j.leukres.2012.03.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD4(pos) T-cell subsets play a role in myelodysplastic syndromes (MDS) pathogenesis and may be affected upon 5-azacitidine (Aza) treatment. Aza enhanced human T(H)1 frequencies in vitro but not in vivo. The proportion of functional FoxP3(pos) regulatory T cells (Treg) was enhanced by Aza in vitro (p<0.0002), and a modest, temporary increase was observed in vivo (p=0.08). The overall number of T(H)17 was reduced both in vitro (p<0.03) and in vivo (p<0.006), indicating that Aza directly affects CD4(pos) polarization during activation in vitro. Upon in vivo treatment in high risk MDS patients, particularly the T(H)17-Treg axis is affected. (C) 2012 Elsevier Ltd. All rights reserved.

引用

收藏

页码：921 / 930

页数：10

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