CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1

被引：2392
作者：
Alkhatib, G
Combadiere, C
Broder, CC
Feng, Y
Kennedy, PE
Murphy, PM
Berger, EA
机构：
[1] NIAID,HOST DEF LAB,NIH,BETHESDA,MD 20892
[2] NIAID,VIRAL DIS LAB,NIH,BETHESDA,MD 20892
来源：
SCIENCE | 1996年 / 272卷 / 5270期
关键词：
D O I：
10.1126/science.272.5270.1955
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the CD4(+) target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T cell line-tropic isolates. The chemokines RANTES, MIP-1 alpha, and MIP-1 beta, which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 messenger RNA was detected selectively in cell types susceptible to macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for macrophage-tropic HIV-1 strains.
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收藏
页码：1955 / 1958
页数：4
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