Relationship between handedness and joint involvement in rheumatoid arthritis

被引：17

作者：

Yaku, Ai ^{[1
]}

Hashimoto, Motomu ^{[2
]}

Furu, Moritoshi ^{[2
]}

Ito, Hiromu ^{[3
]}

Yamakawa, Noriyuki ^{[4
]}

Yamamoto, Wataru ^{[5
]}

Fujii, Takao ^{[2
]}

Matsuda, Fumihiko ^{[6
]}

Mimori, Tsuneyo ^{[1
]}

Terao, Chikashi ^{[6
,7
,8
,9
,10
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Rheumatol & Clin Immunol, Kyoto, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Control Rheumat Dis, Kyoto, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Orthopaed Surg, Kyoto, Japan

[4] Kyoto Katsura Hosp, Dept Rheumatol, Kyoto, Japan

[5] Kurashiki Sweet Hosp, Dept Hlth Informat Management, Kurashiki, Okayama, Japan

[6] Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto, Japan

[7] Kyoto Univ, Grad Sch Med, Ctr Promot Interdisciplinary Educ & Res, Kyoto, Japan

[8] Harvard Med Sch, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[9] Harvard Med Sch, Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA

[10] Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

HAND; CLASSIFICATION; CRITERIA; SEX; AGE;

D O I：

10.1038/srep39180

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rheumatoid arthritis (RA) is characterized by autoimmune chronic joint inflammation, which is worsened by mechanical stress. It is still inconclusive whether joints on the right side or the dominant side get more damaged in RA since the limited number of patients analyzed in the previous study had made it difficult to separately analyze right-handed and left-handed patients. Here, we enrolled 334 RA patients, the biggest number of patients in studies to address this issue and separately analyzed right-handed and left-handed patients. As a result, we observed that joints on the dominant side got clinically and radiologically more involved in the right-handed patients (p <= 0.0030). Importantly, this tendency was also seen in the left-handed patients, while it was not statistically significant due to the small sample size. This tendency was observed in each component of clinical or radiological involvement. Thus, handedness influences the laterality of clinical and radiological joint involvement in RA.

引用

页数：8

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