Graphene Oxide-Based Nanocomposites Decorated with Silver Nanoparticles as an Antibacterial Agent

被引:155
作者
Jaworski, Slawomir [1 ]
Wierzbicki, Mateusz [1 ]
Sawosz, Ewa [1 ]
Jung, Anna [2 ]
Gielerak, Grzegorz [2 ]
Biernat, Joanna [3 ,4 ]
Jaremek, Henryk [3 ]
Lojkowski, Witold [5 ]
Wozniak, Bartosz [5 ]
Wojnarowicz, Jacek [5 ]
Stobinski, Leszek [6 ]
Malolepszy, Artur [6 ]
Mazurkiewicz-Pawlicka, Marta [6 ]
Lojkowski, Maciej [7 ]
Kurantowicz, Natalia [1 ]
Chwalibog, Andre [8 ]
机构
[1] Warsaw Univ Life Sci, Div Nanobiotechnol, Ciszewskiego 8, PL-02786 Warsaw, Poland
[2] Mil Inst Med, Szaserow 128, PL-04141 Warsaw, Poland
[3] Braster SA, Cichy Ogrod 7, PL-05580 Ozarow Mazowiecki, Poland
[4] Warsaw Univ Technol, Fac Mechatron, Boboli 8, PL-02525 Warsaw, Poland
[5] Polish Acad Sci, Inst High Pressure Phys, Sokolowska 29-37, PL-01142 Warsaw, Poland
[6] Warsaw Univ Technol, Fac Chem & Proc Engn, Warynskiego 1, PL-00645 Warsaw, Poland
[7] Warsaw Univ Technol, Fac Mat Sci & Engn, Pl Politechn 1, PL-00661 Warsaw, Poland
[8] Univ Copenhagen, Dept Vet & Anim Sci, Groennegaardsvej 3, DK-1870 Frederiksberg, Denmark
来源
NANOSCALE RESEARCH LETTERS | 2018年 / 13卷
关键词
Graphene oxide; Silver nanoparticles; Antimicrobial properties; OXIDATIVE STRESS; ANTIMICROBIAL APPLICATIONS; IONS; GENERATION; NANOTECHNOLOGY; SONOCHEMISTRY; SPECTROSCOPY; COMBINATION; TOXICITY; ENERGY;
D O I
10.1186/s11671-018-2533-2
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
One of the most promising methods against drug-resistant bacteria can be surface-modified materials with biocidal nanoparticles and nanocomposites. Herein, we present a nanocomposite with silver nanoparticles (Ag-NPs) on the surface of graphene oxide (GO) as a novel multifunctional antibacterial and antifungal material. Ultrasonic technologies have been used as an effective method of coating polyurethane foils. Toxicity on gram-negative bacteria (Escherichia coli), gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and pathogenic yeast (Candida albicans) was evaluated by analysis of cell morphology, assessment of cell viability using the PrestoBlue assay, analysis of cell membrane integrity using the lactate dehydrogenase assay, and reactive oxygen species production. Compared to Ag-NPs and GO, which have been widely used as antibacterial agents, our nanocomposite shows much higher antimicrobial efficiency toward bacteria and yeast cells.
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页数:17
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