Tackling TAMs for Cancer Immunotherapy: It's Nano Time

被引：74
作者：
Yang, Yishun [1 ,2 ]
Guo, Jianfeng [1 ,3 ]
Huang, Leaf [1 ]
机构：
[1] Univ N Carolina, Div Pharmacoengn & Mol Pharmaceut, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA
[2] Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai 201203, Peoples R China
[3] Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 10期
基金：
美国国家卫生研究院;
关键词：
TUMOR-ASSOCIATED MACROPHAGES; MICROENVIRONMENTAL REGULATION; GOLD NANOPARTICLES; CELLS; POLARIZATION; TECHNOLOGIES; INFLAMMATION; RESPONSES; STRATEGY; DELIVERY;
D O I：
10.1016/j.tips.2020.08.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The tumor microenvironment (TME) is a highly complex environment that surrounds tumors. Interactions between cancer cells/non-cancerous cells and cells/non-cell components in the TME support tumor initiation, development, and metastasis. Of the cell types in the TME, tumor-associated macrophages (TAMs) have gained attention owing to their crucial roles in supporting tumors and conferring therapy resistance. Recent developments in nanotechnology raise opportunities for the application of nano targeted drug-delivery systems (Nano-TDDS) in cancer therapy. We focus our discussion on current knowledge of TAMs, and describe recent examples of Nano-TDDS-based TAM modulation, highlighting strategies to overcome in vivo delivery barriers associated with the TME and their potential for clinical translation.
引用
收藏
页码：701 / 714
页数：14
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