Tackling TAMs for Cancer Immunotherapy: It's Nano Time

被引：74
作者：
Yang, Yishun [1 ,2 ]
Guo, Jianfeng [1 ,3 ]
Huang, Leaf [1 ]
机构：
[1] Univ N Carolina, Div Pharmacoengn & Mol Pharmaceut, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA
[2] Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai 201203, Peoples R China
[3] Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Peoples R China
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 10期
基金：
美国国家卫生研究院;
关键词：
TUMOR-ASSOCIATED MACROPHAGES; MICROENVIRONMENTAL REGULATION; GOLD NANOPARTICLES; CELLS; POLARIZATION; TECHNOLOGIES; INFLAMMATION; RESPONSES; STRATEGY; DELIVERY;
D O I：
10.1016/j.tips.2020.08.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The tumor microenvironment (TME) is a highly complex environment that surrounds tumors. Interactions between cancer cells/non-cancerous cells and cells/non-cell components in the TME support tumor initiation, development, and metastasis. Of the cell types in the TME, tumor-associated macrophages (TAMs) have gained attention owing to their crucial roles in supporting tumors and conferring therapy resistance. Recent developments in nanotechnology raise opportunities for the application of nano targeted drug-delivery systems (Nano-TDDS) in cancer therapy. We focus our discussion on current knowledge of TAMs, and describe recent examples of Nano-TDDS-based TAM modulation, highlighting strategies to overcome in vivo delivery barriers associated with the TME and their potential for clinical translation.
引用
收藏
页码：701 / 714
页数：14
相关论文
共 92 条
[1]   Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue [J].
Banciu, Manuela .
NEOPLASIA, 2008, 10 (02) :108-117
[2]   Targeting the microenvironment in solid tumors [J].
Belli, Carmen ;
Trapani, Dario ;
Viale, Giulia ;
D'Amico, Paolo ;
Duso, Bruno Achutti ;
Della Vigna, Paolo ;
Orsi, Franco ;
Curigliano, Giuseppe .
CANCER TREATMENT REVIEWS, 2018, 65 :22-32
[3]   Understanding the tumor immune microenvironment (TIME) for effective therapy [J].
Binnewies, Mikhail ;
Roberts, Edward W. ;
Kersten, Kelly ;
Chan, Vincent ;
Fearon, Douglas F. ;
Merad, Miriam ;
Coussens, Lisa M. ;
Gabrilovich, Dmitry I. ;
Ostrand-Rosenberg, Suzanne ;
Hedrick, Catherine C. ;
Vonderheide, Robert H. ;
Pittet, Mikael J. ;
Jain, Rakesh K. ;
Zou, Weiping ;
Howcroft, T. Kevin ;
Woodhouse, Elisa C. ;
Weinberg, Robert A. ;
Krummel, Matthew F. .
NATURE MEDICINE, 2018, 24 (05) :541-550
[4]   Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm [J].
Biswas, Subhra K. ;
Mantovani, Alberto .
NATURE IMMUNOLOGY, 2010, 11 (10) :889-896
[5]   Optimizing Advances in Nanoparticle Delivery for Cancer Immunotherapy [J].
Caster, Joseph M. ;
Callaghan, Cameron ;
Seyedin, Steven N. ;
Henderson, Kelly ;
Sun, Bp ;
Wang, Andrew Z. .
ADVANCED DRUG DELIVERY REVIEWS, 2019, 144 :3-15
[6]   Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis [J].
Chen, Peiwen ;
Zuo, Hao ;
Xiong, Hu ;
Kolar, Matthew J. ;
Chu, Qian ;
Saghatelian, Alan ;
Siegwart, Daniel J. ;
Wan, Yihong .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (03) :580-585
[7]   In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment [J].
Chen, Qian ;
Wang, Chao ;
Zhang, Xudong ;
Chen, Guojun ;
Hu, Quanyin ;
Li, Hongjun ;
Wang, Jinqiang ;
Wen, Di ;
Zhang, Yuqi ;
Lu, Yifei ;
Yang, Guang ;
Jiang, Chen ;
Wang, Jun ;
Dotti, Gianpietro ;
Gu, Zhen .
NATURE NANOTECHNOLOGY, 2019, 14 (01) :89-+
[8]   Remodeling the Tumor Microenvironment with Emerging Nanotherapeutics [J].
Chen, Qin ;
Liu, Guangxuan ;
Liu, Shuo ;
Su, Hongyan ;
Wang, Yue ;
Li, Jingyu ;
Luo, Cong .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 39 (01) :59-74
[9]   Turning foes to friends: targeting cancer-associated fibroblasts [J].
Chen, Xueman ;
Song, Erwei .
NATURE REVIEWS DRUG DISCOVERY, 2019, 18 (02) :99-115
[10]   Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors [J].
Chen, Yanzuo ;
Song, Wantong ;
Shen, Limei ;
Qiu, Nasha ;
Hu, Mengying ;
Liu, Yun ;
Liu, Qi ;
Huang, Leaf .
ACS NANO, 2019, 13 (02) :1751-1763
12345678910