Neutrophil-CD4+CD25+ T regulatory cell interactions: A possible new mechanism of infectious tolerance

被引：78

作者：

Lewkowicz, Natalia ^{[1
]}

Klink, Magdalena ^{[2
]}

Mycko, Marcin P. ^{[3
]}

Lewkowicz, Przemyslaw ^{[3
]}

机构：

[1] Med Univ Lodz, Dept Periodontol & Oral Mucosal Dis, PL-92213 Lodz, Poland

[2] Polish Acad Sci, Inst Med Biol, Lodz, Poland

[3] Med Univ Lodz, Dept Neurol, Lab Neuroimmunol, PL-92213 Lodz, Poland

来源：

IMMUNOBIOLOGY | 2013年 / 218卷 / 04期

关键词：

Human; Infectious tolerance; Lipopolysaccharide; Neutrophils; T regulatory cells; HEME OXYGENASE-1; CUTTING EDGE; POLYMORPHONUCLEAR NEUTROPHILS; TRYPTOPHAN CATABOLISM; CARBON-MONOXIDE; MESSENGER-RNA; GRANZYME-B; EXPRESSION; IL-10; INTERLEUKIN-10;

D O I：

10.1016/j.imbio.2012.05.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

zzzzzzThis study tested the hypothesis that CD4(+)CD25(+)CD127(low) regulatory T (Treg) cells might induce immunosuppressive properties in apoptotic neutrophils. Treg cells are recognized as a major subset of immune cells possessing potent suppressive properties directed at T effector cells. However, Treg cells have recently been found to inhibit neutrophil function and promote their apoptosis. One of the mechanisms of action of Treg cells is the induction of other suppressor cell populations according to an infectious tolerance model. We showed that LPS-activated Treg cells promote generation of IL-10 and TGF-beta 1, inhibit IL-6 production by PMNs and induce the expression of heme oxygenase-1 (HO-1) and the suppressor of cytokine signaling 3 molecule (SOCS3). However, CD3/CD28-activated Treg cells were seen to promote TGF-beta 1 production, as well as IDO and HO-1 expression by PMNs. These findings suggest that Treg cells might play an important role in the direct control of innate immune responses through the induction of neutrophils with immunosuppressive properties that generate IL-10, TGF-beta 1, IDO and HO-1. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：455 / 464

页数：10

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