Clostridium difficile-related postinfectious IBS: a case of enteroglial microbiological stalking and/or the solution of a conundrum?

被引：22

作者：

Bassotti, Gabrio ^{[1
,3
]}

Macchioni, Lara ^{[2
]}

Corazzi, Lanfranco ^{[2
]}

Marconi, Pierfrancesco ^{[2
]}

Fettucciari, Katia ^{[2
]}

机构：

[1] Univ Perugia, Dept Med, Sch Med, Perugia, Italy

[2] Univ Perugia, Dept Expt Med, Sch Med, Perugia, Italy

[3] Santa Maria della Misericordia Hosp, Gastroenterol & Hepatol Sect, Piazzale Menghini 1, I-06156 Perugia, Italy

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2018年 / 75卷 / 07期

关键词：

Clostridium difficile; Enteric glial cells; Post-infectious irritable bowel syndrome; Toxin B; IRRITABLE-BOWEL-SYNDROME; ENTERIC GLIAL-CELLS; MYENTERIC PLEXUS; NERVOUS-SYSTEM; GUINEA-PIG; TOXIN-B; INTESTINAL PERMEABILITY; FUNCTIONAL DYSPEPSIA; UNITED-STATES; RAT ILEUM;

D O I：

10.1007/s00018-017-2736-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-infectious irritable bowel syndrome is a well-defined pathological entity that develops in about one-third of subjects after an acute infection (bacterial, viral) or parasitic infestation. Only recently it has been documented that an high incidence of post-infectious irritable bowel syndrome occurs after Clostridium difficile infection. However, until now it is not known why in some patients recovered from this infection the gastrointestinal disturbances persist for months or years. Based on our in vitro studies on enteric glial cells exposed to the effects of C. difficile toxin B, we hypothesize that persistence of symptoms up to the development of irritable bowel syndrome might be due to a disturbance/impairment of the correct functions of the enteroglial intestinal network.

引用

页码：1145 / 1149

页数：5

共 56 条

[1] Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation [J].