A Multicenter Retrospective Analysis of the Clinical Features of Pernicious Anemia in a Korean Population

被引:18
|
作者
Song, Ik-Chan [1 ]
Lee, Hyo Jin [1 ]
Kim, Han-Jo [2 ]
Bae, Sang-Byung [2 ]
Lee, Kyu-Taek [2 ]
Yang, Young-Jun [3 ]
Park, Suk-Young [3 ]
Cho, Do-Yeun [4 ]
Kim, Nae Yu [5 ]
Cho, In-Sung [5 ]
Jo, Deog-Yeon [1 ]
机构
[1] Chungnam Natl Univ Hosp, Dept Internal Med, Taejon 301721, South Korea
[2] Soonchunhyang Univ Hosp, Dept Internal Med, Cheonan, South Korea
[3] Daejeon St Marys Hosp, Dept Internal Med, Taejon, South Korea
[4] Konyang Univ Hosp, Dept Internal Med, Taejon, South Korea
[5] Eulji Univ Hosp, Dept Internal Med, Taejon, South Korea
关键词
Anemia; Pernicious; Vitamin B-12; Anti-Intrinsic Factor Antibody; Anti-Parietal Cell Antibody; Helicobacter Pylori; HELICOBACTER-PYLORI INFECTION; PREVALENCE; CANCER;
D O I
10.3346/jkms.2013.28.2.200
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine the approximate incidence and clinical features of pernicious anemia in a Korean population, we retrospectively analyzed clinical data for patients with pernicious anemia who were diagnosed between 1995 and 2010 at five hospitals in Chungnam province. Ninety-seven patients were enrolled, who accounted for 24% of patients with vitamin B-12 deficiency anemia. The approximate annual incidence of pernicious anemia was 0.3 per 100,000. The median age was 66 (range, 32-98) yr, and the male/female ratio was 1.25. Anemia-associated discomfort was the most common symptom (79.4%), followed by gastrointestinal and neurological symptoms (78.4% and 38.1%, respectively). Pancytopenia was found in 36 patients (37.1%), and autoimmune disorders were found in 15 patients (15.5%). Antibody to intrinsic factor was detected in 62 (77.5%) of 80 patients examined, and antibody to parietal cells was detected in 35 (43.2%) of 81 patients examined. Of the 34 patients who underwent tests for Helicobacter pylori, 7 (12.5%) were positive. The anemia-associated and gastrointestinal symptoms resolved completely in all patients after intramuscular injection of cobalamin, whereas neurological symptoms remained in some. In conclusion, pernicious anemia is less frequent in Koreans than in Western populations; however, the clinical features of this disorder in Koreans do not differ from those of Western cases.
引用
收藏
页码:200 / 204
页数:5
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