The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking

被引：43

作者：

Zhang, Houbin ^{[1
]}

Constantine, Ryan ^{[1
,2
]}

Frederick, Jeanne M. ^{[1
]}

Baehr, Wolfgang ^{[1
,3
,4
]}

机构：

[1] Univ Utah, Hlth Sci Ctr, John A Moran Eye Ctr, Dept Ophthalmol, Salt Lake City, UT 84132 USA

[2] Univ Utah, Hlth Sci Ctr, Grad Program Neurosci, Salt Lake City, UT 84132 USA

[3] Univ Utah, Hlth Sci Ctr, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA

[4] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

来源：

VISION RESEARCH | 2012年 / 75卷

关键词：

cGMP phosphodiesterase 6 (PDE6); Prenyl binding protein PrBP/delta; Prenylation; PrBP/delta crystal structure; Small GTPases; Rod photoreceptors; G-protein coupled receptor kinase 1 (GRK1); ROD CGMP PHOSPHODIESTERASE; CYCLIC-GMP PHOSPHODIESTERASE; PHOTORECEPTOR OUTER SEGMENTS; DELTA-SUBUNIT; PDE-DELTA; CATALYTIC SUBUNITS; CAENORHABDITIS-ELEGANS; GTPASE; TRANSPORT; ARL2-GTP;

D O I：

10.1016/j.visres.2012.08.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expressed ubiquitously, PrBP/delta functions as chaperone/co-factor in the transport of a subset of prenylated proteins. PrBP/delta features an immunoglobulin-like beta-sandwich fold for lipid binding, and interacts with diverse partners. PrBP/delta binds both C-terminal C15 and C20 prenyl side chains of phototransduction poly-peptides and small GTP-binding (G) proteins of the Ras superfamily. PrBP/delta also interacts with the small GTPases, ARL2 and ARL3, which act as release factors (GDFs) for prenylated cargo. Targeted deletion of the mouse Pde6d gene encoding PrBP/delta resulted in impeded trafficking to the outer segments of GRK1 and cone PDE6 which are predicted to be farnesylated and geranylgeranylated, respectively. Rod and cone transducin trafficking was largely unaffected. These trafficking defects produce progressive cone-rod dystrophy in the Pde6d(-/-) mouse. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：19 / 25

页数：7

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