Hand perceptions induced by single pulse transcranial magnetic stimulation over the primary motor cortex

被引：8

作者：

Franza, Matteo ^{[1
,2
,3
]}

Sorrentino, Giuliana ^{[1
,2
,3
]}

Vissani, Matteo ^{[4
]}

Serino, Andrea ^{[4
]}

Blanke, Olaf ^{[1
,2
,3
,5
]}

Bassolino, Michela ^{[1
,2
,3
]}

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Sch Life Sci, Ctr Neuroprosthet, Campus Biotech, Geneva, Switzerland

[2] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Sch Life Sci, Lab Cognit Neurosci,Brain Mind Inst, Campus Biotech, Geneva, Switzerland

[3] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Sch Life Sci, Ctr Neuroprosthet, Campus SUVA, Sion, Switzerland

[4] CHU Vaudois, Dept Clin Neurosci, MySpace Lab, Lausanne, Switzerland

[5] Univ Hosp Geneva, Dept Neurol, Geneva, Switzerland

来源：

BRAIN STIMULATION | 2019年 / 12卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Transcranial magnetic stimulation (TMS); Primary motor cortex; Motor evoked potentials; TMS-evoked movements; TMS-evoked hand perceptions; Absolute threshold; VOLUNTARY CONTRACTION; EVOKED-POTENTIALS; PARIETAL CORTEX; MOVEMENT; FACILITATION; MUSCLE; EXCITABILITY; MECHANISMS; RESPONSES; REPRESENTATIONS;

D O I：

10.1016/j.brs.2018.12.972

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: When single pulse transcranial magnetic stimulation (TMS) is applied over the primary motor cortex (M1) with sufficient intensity, it evokes muscular contractions (motor-evoked potentials, MEPs) and muscle twitches (TMS-evoked movements). Participants may also report various hand sensations related to TMS, but the perception elicited by TMS and its relationship to MEPs and evoked movements has not been systematically studied. Objective: The main aim of this work is to evaluate participants' kinesthetic and somatosensory hand perceptions elicited by single-pulse TMS over M1-hand area at different intensities of stimulation and their relation with MEPs and TMS-evoked movements. Methods: We compared the number of MEPs (measured by electromyography), TMS-evoked movements (measured by an accelerometer) and participants' hand perception (measured by verbal report) elicited by TMS at different intensity of stimulation. This way, we estimated the amplitude of MEPs and the acceleration of TMS-evoked movements sufficient to trigger TMS evoked hand perceptions. Results: We found that TMS-evoked hand perceptions are induced at 105% of the individual resting motor threshold, a value significantly different from the threshold inducing MEPs (about 100%) and TMS-evoked movements (about 110%). Our data indicate that only MEPs with an amplitude higher than 0.62 mV and TMS-evoked movements with acceleration higher than 0.42 m/s2 were associated with hand perceptions at threshold. Conclusions: Our data reveal the main features of TMS-evoked hand perception and show that in addition to MEPs and TMS-evoked movements, this is a separate discernible response associated to single-pulse TMS over M1. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：693 / 701

页数：9

共 59 条

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