A 3D POLYHEDRAL METAL-ORGANIC FRAMEWORK AS DRUG CARRIER FOR CONTROLLABLE RELEASE

被引：5

作者：

Zhou, En-Hong ^{[1
,2
]}

Wang, Rui ^{[3
]}

Wu, Jian ^{[4
]}

Qiu, Shuo-Wen ^{[3
]}

Liu, Jian-Qiang ^{[3
]}

Zhong, Hua-Rui ^{[3
]}

Zeng, Hui-Dong ^{[3
]}

Xu, Jing-Wen ^{[3
]}

Jin, Jun-Cheng ^{[1
]}

机构：

[1] West Anhui Univ, Anhui Prov Lab Biomimet Sensor & Detecting Techno, Luan 237012, Anhui, Peoples R China

[2] West Anhui Hlth Vocat Coll, Luan 237012, Anhui, Peoples R China

[3] Guangdong Med Univ, Sch Pharm, Key Lab Res & Dev New Med Mat, Dongguan Key Lab Drug Design & Formulat Technol, Dongguan 523808, Peoples R China

[4] Guangxi Univ Nationalities, Coll Chem & Chem Engn, Guangxi Key Lab Chem & Engn Forest Prod, Nanning 530006, Guangxi, Peoples R China

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2017年 / 31卷 / 03期

关键词：

Drug delivery; Release; Porous MOF; THEORETICAL INSIGHT; NANOPARTICLES;

D O I：

10.4314/bcse.v31i3.9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new fabrication of {[H3O][Cu-6(tpta)(3)(DMA)(4)(COO)]center dot 12H(2)O center dot 7DMA} (1) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1. Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.

引用

页码：457 / 463

页数：7

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