Prognostic landscape of tumor-infiltrating immune cells and immunerelated genes in the tumor microenvironment of gastric cancer

被引：2

作者：

Zhang, Shichao ^{[1
]}

Zeng, Zhu ^{[1
,2
]}

Liu, Yongfen ^{[1
]}

Huang, Jiangtao ^{[1
]}

Long, Jinhua ^{[3
]}

Wang, Yun ^{[1
]}

Peng, Xiaoyan ^{[1
,2
]}

Hu, Zuquan ^{[1
,2
]}

Ouyang, Yan ^{[1
]}

机构：

[1] Guizhou Med Univ, Sch Basic Med Sci, Sch Biol & Engn, Key Lab Biol & Med Engn,Immune Cells & Antibody E, Guiyang 550025, Guizhou, Peoples R China

[2] Guizhou Med Univ, Minist Educ, Key Lab Environm Pollut Monitoring & Dis Control, Guiyang 550025, Guizhou, Peoples R China

[3] Guizhou Med Univ, Affiliated Tumor Hosp, Guiyang 550004, Guizhou, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 18期

基金：

中国国家自然科学基金;

关键词：

gastric cancer; tumor-infiltrating immune cells (TIICs); immune-related genes (IRGs); prognostic value; tumor microenvironment; RESTING DENDRITIC CELLS; REGULATORY T-CELLS; EXPRESSION; SIGNATURE;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumor microenvironment is closely related to the progression and immune escape of tumor cells. Tumor-infiltrating immune cells (TIICs) and immune-related genes (IRGs) are indispensable components of the tumor microenvironment and have been demonstrated to be highly valuable in determining the prognosis of multiple cancers. To elucidate the prognostic value of TIICs and IRGs in gastric cancer, we conducted a comprehensive analysis focusing on the abundances of 22 types of TIICs and differentially expressed IRGs based on a dataset from The Cancer Genome Atlas (TCGA). The results showed that great composition differences in TIICs and immune cell subfractions were associated with survival outcomes in different stages. Additionally, 29 hub genes were characterized from 345 differentially expressed IRGs and found to be significantly associated with survival outcomes. Then, an independent prognostic indicator based on ten IRGs was successfully constructed after multivariate adjustment for some clinical parameters. Further validation revealed that these hub IRGs could reflect the infiltration levels of immune cells. Thus, our results confirmed the clinical significance of TIICs and IRGs in gastric cancer and may establish a foundation for further exploring immune cell and gene targets for personalized treatment.

引用

页码：17958 / 17975

页数：18

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