2,5-diketopiperazines, new chiral auxiliaries for asymmetric Diels-Alder reactions

被引：20

作者：

Le, TXH ^{[1
]}

Bussolari, JC ^{[1
]}

Murray, WV ^{[1
]}

机构：

[1] RW JOHNSON PHARMACEUT RES INST,RARITAN,NJ 08869

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(97)00769-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diketopiperazines have been utilized as chiral auxiliaries for asymetric Diels-Alder reactions. Cyclo-S-phenylalanyl-R-proline (2) was found to be the most promising of these auxiliaries and afforded Diels-Alder adducts in high chemical yield (78-95%), with endo selectivities generally greater than 9:1. The diastereoselectivities observed were comparable to the best previously published values. (C) 1997 Elsevier Science Ltd.

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页码：3849 / 3852

页数：4

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