Avastin Exhibits Therapeutic Effects on Collagen-Induced Arthritis in Rat Model

被引：28

作者：

Wang, Yong ^{[1
,2
]}

Da, Gula ^{[2
]}

Li, Hongbin ^{[2
]}

Zheng, Yi ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chao Yang Hosp, Dept Rheumatol, Beijing 100020, Peoples R China

[2] Inner Mongolia Med Univ, Affiliated Hosp, Dept Rheumatol, Hohhot 010050, Peoples R China

来源：

INFLAMMATION | 2013年 / 36卷 / 06期

关键词：

rheumatoid arthritis; collagen-induced arthritis; vascular endothelial growth factor; avastin; RHEUMATOID-ARTHRITIS; ANGIOGENESIS; EXPRESSION; INFLAMMATION;

D O I：

10.1007/s10753-013-9687-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Avastin is the monoclonal antibody for vascular endothelial growth factor (VEGF). This study aimed to investigate therapeutic effect of Avastin on type II collagen-induced arthritis. Type II chicken collagen was injected into the tails of Wistar rats, and 60 modeled female rats were randomly divided into three groups (n = 20): Avastin group, Etanercept group, and control group. Arthritis index and joint pad thickness were scored, and the pathology of back metapedes was analyzed. The results showed that compared to control group, the arthritis index, target-to-non-target ratio, synovial pathological injury index, serum levels of VEGF and tumor necrosis factor alpha, and VEGF staining were decreased significantly 14 days after Avastin or Etanercept treatment, but there were no significant differences between Avastin group and Etanercept group. These data provide evidence that Avastin exhibits similar effects to Etanercept to relieve rheumatoid arthritis in rat model and suggest that Avastin is a promising therapeutic agent for rheumatoid arthritis.

引用

页码：1460 / 1467

页数：8

共 19 条

[1]

Aaltonen KJ, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0030275, 10.1371/journal.pone.0043508]

[2] Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety [J].

Alonso-Ruiz, Alberto ;

Pijoan, Jose Ignacio ;

Ansuategui, Eukene ;

Urkaregi, Arantxa ;

Calabozo, Marcelo ;

Quintana, Antonio .

BMC MUSCULOSKELETAL DISORDERS, 2008, 9 (1)

[3]

Cha HS, 2007, J RHEUMATOL, V34, P16

[4] Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction [J].

Clavel, Gaeelle ;

Bessis, Natacha ;

Lemeiter, Delphine ;

Fardellone, Patrice ;

Mejjad, Othmane ;

Menard, Jean-Francois ;

Pouplin, Sophie ;

Boumier, Patrick ;

Vittecoq, Olivier ;

Le Loeet, Xavier ;

Boissier, Marie-Christophe .

CLINICAL IMMUNOLOGY, 2007, 124 (02) :158-164

[5] Analysis of vascular gene expression in arthritic synovium by laser-mediated microdissection [J].

Hashimoto, Atsushi ;

Tarner, Ingo H. ;

Bohle, Rainer M. ;

Gaumann, Andreas ;

Manetti, Mirko ;

Distler, Oliver ;

Steinmeyer, Juergen ;

Ulfgren, Ann-Kristin ;

Schulz, Andreas ;

Gay, Steffen ;

Mueller-Ladner, Ulf ;

Neumann, Elena .

ARTHRITIS AND RHEUMATISM, 2007, 56 (04) :1094-1105

[6]

Heinzerling John H, 2006, Curr Surg, V63, P334, DOI 10.1016/j.cursur.2006.06.002

[7] Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis [J].

Konisti, Sofia ;

Kiriakidis, Serafim ;

Paleolog, Ewa M. .

NATURE REVIEWS RHEUMATOLOGY, 2012, 8 (03) :153-162

[8] Treatment with Recombinant Hsp72 Suppresses Collagen-Induced Arthritis in Mice [J].

Luo, Xinjing ;

Zuo, Xiaoxia ;

Mo, Xuanrong ;

Zhou, Yaou ;

Xiao, Xianzhong .

INFLAMMATION, 2011, 34 (05) :432-439

[9] Study of the mechanism involved in angiogenesis and synovial cell proliferation in human synovial tissues of patients with rheumatoid arthritis using SCID mice [J].

Nagashima, M ;

Tanaka, H ;

Takahashi, H ;

Tachihara, A ;

Tanaka, K ;

Ishiwata, T ;

Asano, G ;

Yoshino, S .

LABORATORY INVESTIGATION, 2002, 82 (08) :981-988

[10] The vasculature in rheumatoid arthritis: cause or consequence? [J].

Paleolog, Ewa M. .

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2009, 90 (03) :249-261

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