Genome-wide histone methylation profile for heart failure

被引：118

作者：

Kaneda, Ruri ^{[1
,2
]}

Takada, Shuji ^{[1
]}

Yamashita, Yoshihiro ^{[1
]}

Choi, Young Lim ^{[1
]}

Nonaka-Sarukawa, Mutsuko ^{[2
]}

Soda, Manabu ^{[1
]}

Misawa, Yoshio ^{[3
]}

Isomura, Tadashi ^{[4
]}

Shimada, Kazuyuki ^{[2
]}

Mano, Hiroyuki ^{[1
,5
]}

机构：

[1] Jichi Med Univ, Div Funct Genom, Mibu, Tochigi 3290498, Japan

[2] Jichi Med Univ, Div Cardiovasc Med, Mibu, Tochigi 3290498, Japan

[3] Jichi Med Univ, Div Cardiovasc Surg, Mibu, Tochigi 3290498, Japan

[4] Hayama Heart Ctr, Kanagawa 2400116, Japan

[5] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

GENES TO CELLS | 2009年 / 14卷 / 01期

关键词：

CARDIAC-HYPERTROPHY; MICROARRAY ANALYSIS; GENE-EXPRESSION; CANCER-CELLS; CHROMATIN; RECRUITMENT; STRESS; MOUSE;

D O I：

10.1111/j.1365-2443.2008.01252.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic alterations are implicated in the development of cardiac hypertrophy and heart failure, but little is known of which epigenetic changes in which regions of the genome play such a role. We now show that trimethylation of histone H3 on lysine-4 (K4TM) or lysine-9 (K9TM) is markedly affected in cardiomyocytes in association with the development of heart failure in a rat disease model. High-throughput pyrosequencing performed with ChIP products for K4TM or K9TM prepared from human left ventricular tissue with retained or damaged function also revealed that protein-coding genes located in the vicinity of K4TM marks differ between functional and disabled myocytes, yet both sets of genes encode proteins that function in the same signal transduction pathways for cardiac function, indicative of differential K4TM marking during the development of heart failure. However, K9TM mark-profile was less dependent on the disease status compared to that of K4TM. Our data collectively reveal global epigenetic changes in cardiac myocytes associated with heart failure.

引用

页码：69 / 77

页数：9

共 50 条

[21] Genome-Wide Distribution of DNA Methylation at Single-Nucleotide Resolution [J].

Wong, Eleanor ;

Wei, Chia-Lin .

MODIFICATIONS OF NUCLEAR DNA AND ITS REGULATORY PROTEINS, 2011, 101 :459-477

[22] Genome-wide patterns of histone modifications in fission yeast [J].

Indranil Sinha ;

Marianna Wirén ;

Karl Ekwall .

Chromosome Research, 2006, 14 :95-105

[23] Genome-wide expression profile of LHON patients with the 11778 mutation [J].

Abu-Amero, Khaled K. ;

Jaber, Mohammad ;

Hellani, Ali ;

Bosley, Thomas M. .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2010, 94 (02) :256-259

[24] Prediction of genome-wide DNA methylation in repetitive elements [J].

Zheng, Yinan ;

Joyce, Brian T. ;

Liu, Lei ;

Zhang, Zhou ;

Kibbe, Warren A. ;

Zhang, Wei ;

Hou, Lifang .

NUCLEIC ACIDS RESEARCH, 2017, 45 (15) :8697-8711

[25] Genome-wide promoter methylation of hairy cell leukemia [J].

Arribas, Alberto J. ;

Rinaldi, Andrea ;

Chiodin, Giorgia ;

Kwee, Ivo ;

Mensah, Afua Adjeiwaa ;

Cascione, Luciano ;

Rossi, Davide ;

Kanduri, Meena ;

Rosenquist, Richard ;

Zucca, Emanuele ;

Johnson, Peter W. ;

Gaidano, Gianluca ;

Oakes, Christopher C. ;

Bertoni, Francesco ;

Forconi, Francesco .

BLOOD ADVANCES, 2019, 3 (03) :384-396

[26] Comparative analysis of genome-wide DNA methylation in Neurospora [J].

Hosseini, Sara ;

Meunier, Cecile ;

Nguyen, Diem ;

Reimegard, Johan ;

Johannesson, Hanna .

EPIGENETICS, 2020, 15 (09) :972-987

[27] Genome-wide analysis of differential methylation in pancreatic cancer [J].

Yin, Fan ;

Wang, Huan ;

Men, Yuehua ;

Li, Jidong ;

Hu, Minggen ;

Li, Qingfang .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (05) :5004-5014

[28] Genome-wide analysis of DNA methylation patterns in horse [J].

Lee, Ja-Rang ;

Hong, Chang Pyo ;

Moon, Jae-Woo ;

Jung, Yi-Deun ;

Kim, Dae-Soo ;

Kim, Tae-Hyung ;

Gim, Jeong-An ;

Bae, Jin-Han ;

Choi, Yuri ;

Eo, Jungwoo ;

Kwon, Yun-Jeong ;

Song, Sanghoon ;

Ko, Junsu ;

Yang, Young Mok ;

Lee, Hak-Kyo ;

Park, Kyung-Do ;

Ahn, Kung ;

Do, Kyoung-Tag ;

Ha, Hong-Seok ;

Han, Kyudong ;

Yi, Joo Mi ;

Cha, Hee-Jae ;

Cho, Byung-Wook ;

Bhak, Jong ;

Kim, Heui-Soo .

BMC GENOMICS, 2014, 15

[29] Genome-Wide Analysis of DNA Methylation in Human Amnion [J].

Kim, Jinsil ;

Pitlick, Mitchell M. ;

Christine, Paul J. ;

Schaefer, Amanda R. ;

Saleme, Cesar ;

Comas, Belen ;

Cosentino, Viviana ;

Gadow, Enrique ;

Murray, Jeffrey C. .

SCIENTIFIC WORLD JOURNAL, 2013,

[30] Establishing an analytic pipeline for genome-wide DNA methylation [J].

Michelle L. Wright ;

Mikhail G. Dozmorov ;

Aaron R. Wolen ;

Colleen Jackson-Cook ;

Angela R. Starkweather ;

Debra E. Lyon ;

Timothy P. York .

Clinical Epigenetics, 2016, 8

← 1 2 3 4 5 →